Belgium protectors Thomas Vermaelen and Vincent Kompany pass up a major opportunity with hamstring and crotch wounds separately.
Celtic's Dedyrck Boyata is relied upon to space into their back three close by Toby Alderweireld and Jan Vertonghen.
Panama endured a blow a week ago when key winger Alberto Quintero was governed out of the World Cup with a cracked foot.
Focus back Roman Torres has recouped from the hamstring damage that cursed his development to the competition.
BELGIUM LINE UP1 Thibaut Courtois (Goalkeeper)
2 Toby Alderweireld (Defender)
20 Dedryk Boyata (Defender)
5 Jan Vertonghen (Defender)
15 Thomas Meunier (Defender)
7 Kevin De Bruyne (Midfielder)
6 Axel Witsel (Midfielder)
11 Yannick Carrasco (Midfielder)
14 Dries Mertens (Forward)
9 Romelu Lukaku (Forward)
10 Eden Hazard (Forward)
PANAMA LINE U1 Jaime Penedo (Goalkeeper)
2 Michael Murillo (Defender)
5 Roman Torres (Defender)
4 Fidel Escobar (Defender)
15 Éric Davis (Defender)
6 Gabriel Gomez (Midfielder)
8 Édgar Barcenas (Midfielder)
11 Armando Cooper (Midfielder)
20 Anibal Godoy (Midfielder)
21 Jose Luis Rodriguez (Midfielder)
7 Blas Pérez (Forward)
Gathering G gets in progress with an intriguing conflict between Panama, who have officially left a mark on the world, and Belgium, who would like to make history of their own.
A national occasion was announced after Panama fixed capability in October and the whole nation will grind to a halt as they a play a World Cup diversion for the simple first time.
Individual debutants Iceland appeared against Argentina that littler nations require not be overawed against more magnified rivals. Panama will unquestionably not make a regressive stride and their ultra-focused and physical approach will give Belgium's skilled craftsmen an unpleasant ride.
While Panama won only three times in 10 diversions in definite qualifying, Belgium set another joint European record of 43 objectives scored, with 11 from Romelu Lukaku – two more than the Panamanians oversaw altogether.
Their maturing group could be ruthlessly uncovered by a Belgium side goal on ensuring their 'Brilliant Generation' doesn't blur away. Come mid-July, the Belgians are trusting they get their very own national occasion.
VIEW FROM BOTH CAMPS
Belgium head coach Martinez: "World Cups don't regard any ages. What they regard is your main event in those three recreations that we've earned the privilege to have, and afterward the privilege to develop in the competition and perceive how far we can go.
"France, Germany, Brazil, Argentina, Spain – the cutting edge victors - have favorable position, since it's relatively similar to they can demonstrate to the present players industry standards to approach a World Cup."
Panama protector Roman Torres on their World Cup make a big appearance: "Numerous individuals will cry. I believe I will be one of those individuals as well, in light of the feeling and to feel the centrality of tuning in to the national song of praise at a World Cup."