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A blog writing about biotech news, basic knowledge, hotspot, protocol,etc.

Key Targets In Molecular Characteristics Of Parkinsonâ€™s Disease At Different Stages Of Progression

2024-04-26 09:55

The neuroinflammation associated with Parkinson’s disease (PD) has attracted widespread attention due to abnormal protein aggregation, among which glycosylation, as a post-translationa… Read More

FOXO1- Key Protein That Can Control The Lifespan Of Car-T Cells

2024-04-26 09:29

Nowadays, CAR-T cell therapy has completely changed the treatment of certain types of cancer. The longer these CAR-T cells survive in the patient’s body, the more effective their respo… Read More

A New Study Has Successfully Constructed A Human Neuron Model That Simulates The Diffusion Of Tau Protein Aggregates

2024-04-26 08:53

In a new study, researchers from the Will Cornell School of Medicine in the United States have developed an innovative human neuron model that can effectively simulate the diffusion of tau p… Read More

A New Mechanism Of Glucocorticoid Inhibition Of Inflammation

2024-04-26 08:23

Cortisone and other related glucocorticoids are highly effective in inhibiting excessive immune responses. But before this, people knew very little about how they did it. Now, in a new stud… Read More

A New Mechanism Linking Poor Diet With Increased Cancer Risk

2024-04-26 07:53

In a recent study, the research team of the National University of Singapore and the Singapore Science and Technology Research Bureau has made groundbreaking progress. These new findings rev… Read More

Activating GCN2 Can Metabolize Reprogrammed T Cells And Enhance Their Anti-Tumor Immunity

2024-03-19 09:09

Researchers from the University of Toronto published a research paper titled “Ex vivo activation of the GCN2 pathway metabolically reprograms T cells, leading to enhanced adoptive cell… Read More

The Release Of Special Inhibitory Pathways May Promote The Bodyâ€™s Immune Response Against HIV Infection

2024-03-19 09:08

During antiretroviral therapy, the persistent presence of HIV-1 may be due to its establishment of a long-lived virus library in quiescent immune cells. Recently, an article titled “TG… Read More

RHBDL4 â€“ A Novel Regulatory Mechanism For Controlling The Bodyâ€™s Immune System

2024-03-19 09:08

Toll-like receptor 4 (TLR4) is a central regulatory factor of innate immunity in the body, mainly able to recognize the lipopolysaccharide cell wall components of bacteria and induce cytokin… Read More

Revealing Prognostic Markers For Small Cell Lung Cancer

2024-03-19 09:07

In a new study, a research team led by Professor Zhang Peng of the Shanghai Lung Hospital affiliated with Tongji University, China, Professor Zhou Hu of the Chinese Academy of Sciences Shang… Read More

Regulatory Mechanism Of RAS Palmitoyltransferase

2024-03-19 09:07

RAS participates in multiple signaling pathways, and post-translational modifications regulate the subcellular localization of RAS to regulate downstream signal transduction. Among them, pal… Read More

The Molecular Mechanism Of Fusion Protein Intercepting Gene Regulators And Inducing Childhood Cancer

2024-03-19 09:06

The occurrence of many childhood cancers often begins with molecular hijacking. Recently, a research report titled “Heterotypic interactions can drive selective co-condensation of prio… Read More

The Influence Of Age And Number Of Mutations On The Size Of Clonal Hematopoiesis

2024-03-19 09:05

Hainan Medical College’s Ren Ruibao, Cai Wangwei, and Shanghai Jiao Tong University’s Chen Zhu jointly published a research paper on PNAS titled “The impact of age and numb… Read More

Research Progress On Structural Characteristics And Enzyme Activity Regulation Mechanisms Of Viral Topoisomerases

2024-03-19 09:04

Recently, Deng Zengqin’s team from the Chinese Academy of Sciences Wuhan Virus Research Institute/Antiviral Research Center completed the latest research achievement entitled “St… Read More

Genetic Anxiety Switch In The Body

2024-03-19 09:02

Recently, a research report titled “An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behavior in mice and humans” was… Read More

How HIV Capsid Enters The Nuclear Pore Barrier Pathway

2024-02-20 10:40

In a new study, Dr. David Jacques, a medical researcher at the University of New South Wales in Australia, and his team discovered how the human immunodeficiency virus (HIV) breaks through t… Read More

The Mechanism By Which Leukemia Stem Cells Promote Their Own Growth After Chemotherapy

2024-02-20 10:38

The mystery of why myeloid leukemia begins to grow again after chemotherapy kills most malignant cells and how to prevent growth through reused drugs may be solved through new research. The… Read More

Potential Therapeutic Targets For Human Inflammatory Bowel Disease And Colitis Induced Colorectal Cancer

2024-02-20 10:38

Intestinal inflammation can trigger a vicious cycle that disrupts the sensitive relationships between food, digestive acids, microorganisms, and the immune system, further promoting inflamma… Read More

TRIB3-TRIM8 Complex Regulates HNF4Î‘ Stability To Promote The Progression Of Non-Alcoholic Fatty Liver Disease

2024-02-20 10:34

Hepatocellular endoplasmic reticulum stress plays an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Hepatonuclear factor 4 α (HNF4α) reduced exp… Read More

Acinar-Ductal Cell Rearrangement Drives Branching Morphogenesis Of The Murine Pancreas In An IGF/PI3K Dependent Manner

2024-02-18 09:28

Many epithelial organs undergo branching morphogenesis during development, resulting in the construction of complex dendritic networks and the acquisition of specialized tissue structures. U… Read More

Reveal A New Immune Pathway For The Treatment Of Bone Metastasis In Breast Cancer

2024-02-18 09:27

Immunotherapy is a very promising method for the treatment of metastatic breast cancer, which can provide new possibilities for treatment. Although checkpoint inhibitors show some hope in th… Read More

PLA2G7-A New Breakthrough In Reversing The Immunosuppressive Microenvironment Of Liver Cancer

2024-02-18 09:27

Recently, a team led by Dong Ling from Zhongshan Hospital affiliated with Fudan University and Zhang Si from the School of Basic Medicine at Fudan University jointly published a new study in… Read More

The Special Protective Effects Of Breast Milk

2024-02-18 09:26

Breastfeeding can provide significant health benefits for newborns and infants by providing nutrition, immune protection, and shaping the gut microbiota. Although scientists have long believ… Read More

The New Role Of STING In The Human Innate Immune System

2024-01-22 09:40

When pathogens invade the body, the innate immune system will play a role in resisting the invading pathogens. The innate immune system is the first line of defense. It can accurately detect… Read More

Molecular Mechanisms Underlying The Development Of Colitis In Cancer Immunotherapy Induced Patients

2024-01-22 09:01

Immune checkpoint inhibitors can stimulate the body’s anti-tumor immune system, but they can also have toxic effects called immune-related adverse events (irAEs). Colitis is a common a… Read More

SARS-Cov-2 Can Infect Dopaminergic Neurons

2024-01-22 07:32

In a new study, researchers from the Will Cornell Medical Center, Memorial Sloan Kettering Cancer Center, and Columbia University’s Wagros School of Internal and External Medicine poin… Read More

CD276: A New Target For The Treatment Of Brain Metastatic Cancer

2024-01-22 06:26

Researchers from the University of Lausanne in Switzerland have published a research paper in the Cancer Cell journal titled “Interrogation of endothelial and mural cells in brain meta… Read More

In Situ Regeneration Research Of Inner Hair Cells In A Mouse Injury Model Induced By Ectopic Expression Of Tbx2 And Atoh1

2024-01-22 02:49

The Development journal published a research paper online titled “In situ regeneration of inner hair cells in the damaged cochlea by temporally regulated coexpression of Atoh1 and Tbx2… Read More

Research Progress On The Interaction Mechanism Between Bunyavirus And Host

2024-01-22 02:49

Recently, the team of Wang Hualin, Deng Fei, and Ning Yunjia from the Chinese Academy of Sciences Wuhan Virology Research Institute/National Viral Resource Bank published the research papers… Read More

Nuclear Membrane Proteins Promote Yellow Virus Replication

2024-01-22 02:47

Yellow viruses, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), are mostly transmitted through mosquito vectors and are currently one of the most wid… Read More

MRE11 Releases CGAS From Nucleosome Blockade To Prevent Cancer Development

2024-01-22 02:38

Every time cancer cells divide, they cause damage to their own DNA molecules. For a long time, scientists including Gao á v Gupta Bo, associate professor of radiation oncology at the… Read More

New Research Has Found Biomarkers For Predicting The Risk Of Human Cell Aging And Death

2024-01-02 09:29

As cells age, they experience aging, a state where they stop growing but continue to release inflammatory and tissue-degrading molecules. When a person is young, the immune system will respo… Read More

MSL2 Ensures The Expression Mechanism Of Mammalian Biallelic Genes

2024-01-02 09:29

Have you ever thought about why every chromosome in our cells has two copies? During the breeding process, we obtain a copy from each of our parents. This means that we also obtained two cop… Read More

Protein IKAROS Regulates The Development Of B Cells

2024-01-02 09:28

The nucleus is a busy place. Cellular proteins twist and pull DNA, folding the genome into complex three-dimensional structures that support the function of its coding regions. This arrangem… Read More

The Reasons For The Therapeutic Effect Of CTLA-4 Inhibitors Being Sluggish

2024-01-02 09:28

As the “predecessors” in immune checkpoint inhibitors, the development of anti-CTLA-4 monoclonal antibodies in recent years has not been ideal. From the perspective of approved i… Read More

Themis2 Can Regulate Natural Killer Cell Immune Memory

2023-12-04 10:34

Immune memory is a hallmark of the adaptive immune system in the body. Although natural killer cells (NK cells) are essential innate immune cells for the host’s immediate defense syste… Read More

The Regulation Of Cancer Stem Cells And Its Implications For Targeted Cancer Therapy

2023-12-04 10:18

Tumor occurrence and progression are considered to be a complex progressive process involving multi-level reactions and accumulation of mutations. In the past few decades, there have been ma… Read More

Molecular Mechanism Behind MAF Protein Promoting Breast Cancer Metastasis

2023-12-04 09:57

Breast cancer is the most common type of cancer among women. There are more than 2 million new cases of breast cancer every year. The survival rate of patients is very high, about 90%, when… Read More

CDK4 Is Expected To Be Used In The Treatment Of Type 2 Diabetes

2023-12-04 09:47

Type 2 diabetes affects more than 500 million people worldwide. In a new study, researchers from Weill Cornell Medical College in the United States found a new pathway that stimulates insuli… Read More

PLSCR1 Is A Cellular Autonomous Defense Factor That Resists SARS-Cov-2 Infection

2023-11-04 08:01

Earlier this month, multiple health departments confirmed that BA.2.86- a highly mutated SARS-CoV-2 virus that causes COVID-19- poses a risk of rapid transmission in countries around the wor… Read More

Discovering New Protein Families And Folds Using Artificial Intelligence Tools

2023-11-04 07:26

In a new study, researchers from the Swiss Institute of Bioinformatics and the University of Basel have discovered a treasure trove of uncharacterized proteins. In the recent deep learning r… Read More

DCC May Help Identify Human Parkinsonâ€™s Disease

2023-11-04 07:02

At present, the diagnosis of Parkinson’s disease is mainly based on clinical standards, but the sensitivity of clinical standards is often limited before most dopaminergic neurons are… Read More

The Three-Dimensional Structure Of Type A GABA Receptors In Natural State

2023-11-04 06:11

In a new study, researchers from the University of Health and Science of Oregon in the United States revealed the molecular structure of a receptor crucial for brain development and function… Read More

Virus ADP Ribotransferase Couples RNA With Host Protein

2023-09-25 09:29

Prior to this, people had always believed that RNA and protein only interacted briefly during cellular processes. In a new study, researchers from the Max Planck Institute of Land Microbiolo… Read More

Synaxin-6 Promotes The Progression Of Hepatocellular Carcinoma By Activating The USF2/LC3B Axis

2023-09-25 04:00

Hepatocellular carcinoma accounts for over 80% of all primary liver cancers and is the fourth leading cause of cancer-related deaths worldwide. The five-year survival rate of hepatocellular… Read More

ACSS2 â€“ A Promising New Anticancer Target

2023-09-25 03:07

A recent study published in Nature Cancer shows that intervening in the metabolism of acetic acid by cancer cells through ACSS2 is not only an effective approach, but also an unexpected gain… Read More

In Situ PEG Modification Of CAR-T Cells Can Alleviate Cytokine Release Syndrome And Neurotoxicity

2023-09-22 07:17

In recent years, cancer researchers have cheered the arrival of chimeric antigen receptor (CAR) T-cell therapy, which has achieved encouraging results and changed the treatment methods of va… Read More

Scientists Have Found 32 Proteins Related To Dementia In The Blood Of Middle-aged People Based On 25 Years Of Data!

2023-08-17 08:35

Genome-wide association studies on Alzheimer’s disease (AD) have shown that its biological process is very complex and not limited to the accumulation of β Amyloid protein (A&beta&hell…Read More

Host Limiting Factor ProtÎ‘ Can Inhibit HIV Infection In The Body

2023-08-17 07:55

In a new study, researchers from research institutions such as the Walter Reed Army Research Institute in the United States confirmed previous research on host limiting factors for HIV-1. Th… Read More

Drugs Targeting The Protein Cypa Have The Potential To Treat A Range Of Poxviruses, Including Monkeypox And Smallpox Viruses

2023-08-17 06:46

In a new study, researchers from the University of Oxford, the University of Cambridge, and the Pierbright Institute in the UK have discovered a new treatment method that may be more durable… Read More

A Novel Mechanism Of ID1 Regulation In The Initiation And Progression Of Acute Myeloid Leukemia In The Bone Marrow Microenvironment

2023-08-15 11:07

Wang Lan’s research group of the Chinese Academy of Sciences Shanghai Institute of Nutrition and Health published the research achievement entitled “The cell non-autonomous funct… Read More

TLR9 Agonists Can Act As In Situ Anti-Tumor Vaccines

2023-07-26 08:44

Osteosarcoma (OS) is a highly malignant stromal tumor composed of mesenchymal cells that produce osteoid and immature bone. The peak of incidence is in the second decade after birth. Althoug… Read More

TRAF2 Is A Potential New Target For The Treatment Of Advanced Renal Cell Carcinoma

2023-07-25 11:05

Renal cell carcinoma (RCC) is one of the top ten most common malignant tumors in both males and females worldwide, accounting for 4.2% of all new cancer cases. Clear cell carcinoma of the ki… Read More

PPARÎ‘ Pretreatment Of Agonist WY14643 Reduced Cardiomyopathy Caused By Mitochondrial Dysfunction In The Hearts Of Lipopolysaccharide Treated Mice

2023-07-21 11:32

Sepsis is defined as Systemic inflammatory response syndrome (SIRS), which is the most common cause of death in ICU. The main reason for the increased mortality rate of sepsis is septic shoc… Read More

Intranasal Injection Of Human Mitochondrial Protein Alleviates The Progression Of Parkinsonâ€™s Disease

2023-07-21 11:00

Parkinson’s disease (PD) is a common neurodegenerative disease, which has become a serious problem worldwide. The typical clinical features of Parkinson’s disease include motor m… Read More

Structure And Function Of The RAD51B-RAD51C-RAD51D-XRCC2 Protein Complex

2023-07-01 07:47

Homologous recombination is a basic process of life, which is necessary to protect and restart broken replication forks, repair chromosome breaks and exchange genetic material during meiosis… Read More

B4GALT1 Promotes Immune Escape In Lung Adenocarcinoma

2023-07-01 07:08

With the popularization of lung cancer screening and the clinical application of computed tomography (CT), the number of detected pulmonary nodules has significantly increased, many of which… Read More

Mutated TG2 Enzyme Promotes The Progression And Diffusion Mechanism Of Prostate Cancer

2023-07-01 06:00

In a new study, researchers from Nottingham Trent University in the UK identified how a specific enzyme plays a key role in making prostate cancer more invasive and difficult to treat. They… Read More

By Activating Oct4, Premature Aging Mouse Cells Can Recover Their Vitality

2023-07-01 04:00

Aging seems to be an irresistible natural law, and at the same time, how to “fight aging and achieve immortality” has become an eternal research topic. Nowadays, thanks to the ra… Read More

Three Dimensional Structure Of The Smallest Programmable Nuclease Tnpb

2023-05-15 12:03

In a new study, professor Virginijus Šikšnys from the Life Sciences Center (VU-LSC) of Vilnius University in Lithuania and his research team cooperated with Professor Guillermo… Read More

Scientists Have Screened New Serotonin Transporter Inhibitors From Over 20 Billion Molecules

2023-05-15 10:55

Highlights •Large-library docking finds conformationally and target-selective SERT inhibitors •Cryo-EM supports the computationally predicted structure •The inhibitors are ant… Read More

Insufficient Sleep Can Lead To Dementia, Affecting The Clearance Of Toxic Proteins In The Brain And Increasing The Risk Of Dementia

2023-05-12 13:11

This study reveals how sleep deprivation affects microglia, and finds that TREM2 mediates sleep deprivation-induced microglia overactivation, and β-Amyloid protein (Aβ） depo… Read More

Molecular Mechanism Of Melanoma Induced By CDK13 Mutant Protein

2023-05-12 12:43

The RNA surveillance pathway can detect and interpret defective transcripts to ensure the fidelity of RNA. Recently, in a research report entitled “Oncogenic CDK13 mutations infinite n… Read More

Novel CAR-T Cell Therapy With Potential For Treating Human Solid Tumors

2023-04-25 11:43

Because of the expansion and persistence of CAR-T cells, patients receiving CAR-T cells rich in memory T cells tend to have better disease control. Human memory T cells, including stem cell… Read More

PROTAC R&D To Achieve The Latest Progress

2023-04-25 11:20

Recently, the Li Zigang/Yin Feng research group at the Shenzhen Graduate School of Peking University published a research paper titled “Targeted biomolecule regulation platform: a Spli… Read More

Discovering An Autoimmune Inflammatory Disease Induced By LYN Gene Mutation

2023-04-25 10:35

Scientists from institutions such as the National Institute of Allergy and Infectious Diseases in the United States have identified an autoimmune disease induced by mutations in the LYN gene… Read More

Special Protein FAM193A With Novel Anti-Tumor Activity

2023-04-25 10:14

Scientists from institutions such as the Anschutz School of Medicine at the University of Colorado have discovered and characterized a specific protein that is primarily involved in the spec… Read More

M6A Targeted Modification Can Improve Immune Checkpoint Therapy

2023-03-30 10:05

The immune system acts as a guardian of the host by initiating an immune response to harmful pathogens and tumor cells. However, overreaction is the cause of chronic or excessive inflammatio… Read More

The Role Of The Third Intracellular Ring Of GPCR In GPCR Signal Conduction Mechanism

2023-03-30 09:49

In a new study, American researchers have discovered the role of the third intracellular loop of GPCR in the GPCR signal transduction mechanism, indicating the possibility of adopting more t… Read More

The Base Editor Is Expected To Be Used For The Treatment Of CD3Î” Severe Combined Immunodeficiency

2023-03-30 09:34

In a new study, researchers from research institutions such as the University of California, Los Angeles, discovered that advanced genome editing technology may be able to be used for a rare… Read More

Understand The Mechanism Of Action Of CFTR To Better Treat Cystic Fibrosis

2023-03-30 08:44

In a new study, researchers from St. Jude’s Children’s Research Hospital and Rockefeller University in the United States combined their expertise to gain a better understanding o… Read More

Interferon-gamma (IFNG) Drives Regulatory T Cells To Restrain DC1-mediated Priming Of Cytotoxic T Cells Against Lung Cancer

2023-03-02 10:30

Immunotherapy – drug therapy that stimulates the immune system to attack tumors – has a good effect on some types of cancer, but its effect on lung cancer is mixed. A new study… Read More

ROR2 May Be A Potential Biomarker Of Prostate Cancer

2023-03-02 09:02

Prostate cancer (PCa) is the main cause of cancer-related deaths in men. Androgen deprivation therapy (ADT) is still the standard systemic treatment, but patients always progress to metastat… Read More

AMPK Activation Is A Promising Strategy To Reduce The Risk Of Melanoma

2023-03-02 08:05

Skin cancer is the most common cancer in the United States, with about 5 million cases every year. Melanoma is less common than other types of skin cancer, including basal cell carcinoma (BC… Read More

Autoimmunity In Downâ€™s Syndrome Via Cytokines

2023-03-02 06:29

In a new study, researchers from the Icahn Medical College in Mount Sinai, the United States, determined which parts of the immune system of patients with Down’s syndrome had problems… Read More

The Combination Of PD1-IL2v And Anti-PD-L1 Can Destroy The Resistance Of Cancer To Immunotherapy

2023-02-17 06:48

Immunotherapy is a method of treating cancer by reprogramming the immune system of patients to attack their tumors. This cutting-edge treatment has had a significant impact on the treatment… Read More

The Antiviral APOBEC3 Protein Actually Promotes HIV To Enter The Latent State

2023-02-17 06:31

In a new study, researchers described a discovery that violated the rules of the game in this field. Their research results show that a host protein family, which has long been considered as… Read More

Restoring Lost Epigenetic Information Can Make Aging Mammals Rejuvenate

2023-02-17 06:06

An international study lasting for 13 years has shown for the first time that the degradation of the way DNA is assembled and regulated – the so-called epigenetics – can drive th… Read More

CAR-T Cell Therapy Is Expected To Eliminate Residual Tumor Cells After Solid Tumor Surgery

2023-02-17 05:44

In a new preclinical study, researchers from the Perelman School of Medicine at the University of Pennsylvania found that as a method of reprogramming patients’ autoimmune cells to att… Read More

CDK4 â€“ A Master Regulator Of The Cell Cycle

2022-12-23 08:36

The mammalian cell cycle can be divided into four stages, namely Gap 1 (G1 stage), Synthesis (S stage), Gap 2 (G2 stage), and Mitosis (M stage). Its sequence and time are crucial for the acc… Read More

Occluding The ACE2 Receptor, Renders All Mutants Incapable Of Infection!

2022-12-23 08:08

With successive waves of uncapping, enhancing disease resistance has become one of the most important things at present. Vaccines are the most effective medicines to fight the coronavirus at… Read More

$Targeting PI4KA Increases Chemosensitivity Of Refractory Leukemia By Regulating ERK/AMPK/OXPHOS Axis$

Targeting PI4KA Increases Chemosensitivity Of Refractory Leukemia By Regulating ERK/AMPK/OXPHOS Axis

2022-12-23 07:08

Leukemia is a highly aggressive hematological malignancy characterized by extensive molecular changes that affect clinical outcomes and provide potential drug development targets. However, t… Read More

TRPC Can Significantly Regulate The Pathogenesis Of Endotoxemia

2022-12-23 06:42

Recently, Professor Cao Wei’s team from the School of Chemistry and Pharmacy of Northwest Agriculture and Forestry University published a paper entitled “TRPC channels blockade o… Read More

New Research Finds That Secretory Gel Protein Inhibits Cancer Immunity

2021-09-29 02:22

How does the human body fight against tumor formation? The human immune system includes many kinds of immune cells, among which type 1 conventional dendritic cells (cDC1) are essential for e… Read More

A New Method Of Rewriting The Genetic Code Of Bacterial Genome Can Add Many Unnatural Amino Acids To The Protein At One Time

2021-09-25 03:45

Almost all organisms build their proteins by combining 20 different amino acids. In order to add new amino acids to this combination, scientists have redesigned genes and other protein-build… Read More

Foxp3 Mediates Immune Tolerance Of Thymic Treg Cells Through IL-2

2021-04-21 09:41

Regulatory T (Treg) cells play an important role in the establishment and maintenance of immune tolerance. Most Treg cells express CD25 molecule, which has a high affinity with IL-2. After a… Read More

Inhibition Of TMEM16 Can Effectively Block The Production Of Syncytia Induced By SARS-CoV-2 Infection

2021-04-21 09:30

Since the outbreak of COVID-19, it still seriously affects our lives. Therefore, the research on the pathogenesis of COVID19 and the development of related drugs will help to alleviate the e… Read More

Targeted Nucleotide Rescue Factor DNPH1 Can Improve The Sensitivity Of Cancer Cells To PARP Inhibitors

2021-04-21 09:22

Mutations in BRCA1 or BRCA2 tumor suppressor genes increase the risk of breast and ovarian cancer. In clinical practice, these cancer patients often receive targeted poly ADP ribose polymera… Read More

Scientists May Be Able To Turn Off The Key Proteins In Cancer Cells That Depend On For Survival

2021-03-15 08:42

In a research report entitled “Specific inhibition of the Survivin – CRM1 interaction by peptide modified molecular tweezers” published in the journal Nature Communications… Read More

â€œNew Partnerâ€ Of PD-1 Antibody: Fusion Of IL-21 Improves Anti-tumor Efficacy

2021-03-15 08:31

PD-1 inhibitors restore the activity of tumor-responsive CD8 + T cells by eliminating the inhibition induced by PD-1 and PD-L1 interaction. This therapy has brought great changes to cancer t… Read More

New Co-stimulatory Signal Enables CAR-T To Show Its Potential In The Treatment Of Solid Tumors

2021-02-03 10:04

Chimeric antigen receptor (CAR) expressing T cells (CAR-T therapy) is one of the major breakthroughs in the field of cancer treatment in recent years, and has achieved excellent results in t… Read More

AIM2 Can Regulate The Normal Function Of T Cells And Play A Key Role In Reducing Autoimmune Diseases

2021-02-03 08:22

Many of the molecules in our body help our immune system stay healthy without overreacting to cause problems for our immune cells, such as autoimmune diseases. There’s a molecule calle… Read More

Blocking The Effect Of ATM / ATR On Serine TRNA Synthetase Can Reduce Tumor Growth

2021-01-04 08:32

Most organisms need oxygen to grow and develop, even cancerous tumors. That’s why in the absence of oxygen, tumors can easily grow new blood vessels, creating a new lifeline for surviv… Read More

Protein ABCB1 Warps And Squeezes Make Cancer Resistant

2021-01-04 08:01

In 1986, Kazumitsu Ueda, a Japanese cell biochemist, discovered that a protein called ABCB1 can transport a variety of chemotherapy drugs from some cancer cells, making them resistant to tre… Read More

New Research Reveals The Mutation Of Cholesterol Transporter ABCA13 Associated With Schizophrenia

2021-01-04 07:38

Scientists have long suspected that the mutation of cholesterol transporter ABCA13 in cells is related to mental illness, but it is difficult to prove this, and it is difficult to determine… Read More

Research Reveals That The Endoplasmic Reticulum P5A ATPase/CATP-8 Maintains The â€œidentityâ€ Of The Endoplasmic Reticulum By Removing Ectopic Proteins

2020-11-23 09:17

The correct positioning of membrane proteins on the corresponding organelles is important for maintaining the specific “identity” and physiological functions of the organelles. T… Read More

In SARS-CoV-2 Infection And Cytokine Shock Syndrome, TNF-Î± And IFN-Î³ Cause Inflammatory Cell Death, Tissue Damage And Death

2020-11-23 07:53

The COVID-19 pandemic continues to cause major illness and death, while treatment options are still limited. In a new study, researchers from the St. Jude Children’s Research Hospital… Read More

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