2020-06-24 07:08
Scientists from the Gulbenkian de Ciência Institute (IGC) led by Luís Moita have discovered that a hormone believed to treat obesity reduces the body’s resistance to bacte… Read More
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A blog writing about biotech news, basic knowledge, hotspot, protocol,etc.
2020-06-24 06:48
Researchers at the Department of Radiation Oncology and Molecular Radiology at the Kimmel Cancer Center at Johns Hopkins University have discovered a lipid-modulating protein that transfers… Read More
2020-05-21 08:37
A small study of 8 patients in Greece found that the clinically approved anti-inflammatory drug anakinra (anakinra, which is essentially an IL-1 inhibitor) for the treatment of rheumatoid ar… Read More
2020-05-21 07:18
Data from COVID-19 patients indicate that smokers are at higher risk of complications. The researchers published an article in the journal Developmental Cell that one of the possible reasons… Read More
2020-05-19 09:01
Recently, in a study published in Cancer Research, scientists from New York University and other institutions have found that a key immune signal may play a previously unknown role in turnin… Read More
2020-05-19 08:39
The World Health Organization announced the global pandemic of COVID-19 in March 2020, the second pandemic in the 21st century. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) i… Read More
2020-05-19 08:28
Recently, a team led by the University of Bonn discovered how TLR8 plays an important role in defending human cells against invaders. It was found that when RNaseT2 and RNase2 cut the ribonu… Read More
2020-05-19 07:08
Researchers have identified microscopic features that may make this pathogen more infectious than the SARS virus and can serve as drug targets.
With nearly 100,000 people infected with SARS… Read More
2020-05-19 06:57
As infections from SARS-CoV-2 spread from Wuhan, China, to all over the world, researchers are scrambling to develop a vaccine, and life science companies are providing help.
On January 28… Read More
2020-05-19 06:11
Cancer immunotherapy is continuing to revolutionize the means of patient care, bringing hope and good news to patients. However, only a minority of patients respond to treatment, which drive… Read More
2020-03-30 09:49
According to a recent study by the Francis Crick Institute, the immune system response to respiratory infections is constantly changing, depending on the history of previous unrelated infect… Read More
2020-03-30 09:37
In a new study, researchers from the National Institutes of Health reported that the experimental antiviral drug remdesivir (also known as GS-5734) successfully prevented rhesus monkeys infe… Read More
2020-02-24 05:25
The immune system uses its mitochondria to self-stimulate innate and adaptive responses against infection. Reactive oxygen species (ROS), immunogenic mitochondrial DNA (mtDNA) and even whole… Read More
2020-02-22 13:14
It is well-known that proteins are the cornerstone of life and play a key role in all biological processes. Therefore, understanding how they interact with the environment is critical to dev… Read More
2020-01-02 07:54
Gut microorganisms play an important role in intestinal nutrition absorption, body metabolism, immune development, and resistance to pathogens. Imbalance of intestinal microecology can not o… Read More
2020-01-02 07:53
In the face of current demographic changes, aging is a serious public health problem: by 2050, the proportion of the global population aged 60 years and over will almost double. Recently, re… Read More
2019-12-17 09:04
Recently, researchers from Ghent University Hospital in Belgium published an article entitled “A human immune dysfunction syndrome characterized by severe hyperinflammation with a homo… Read More
2019-12-17 06:16
Recently, researchers from the University of Copenhagen in Denmark have discovered how certain types of proteins keep damaged DNA stable, thereby preserving its function and integrity. The n… Read More
2019-11-21 01:58
Recently, scientists at Trinity College Dublin have identified for the first time a family of proteins that may be directly linked to lower blood sugar levels in obese patients with type 2 d… Read More
2019-11-21 01:51
In a recent study published in The Journal of Neuroscience, scientists from Mount Sinai Hospital have discovered that a specific protein called RGS4 (Regulator of G protein signaling 4) may… Read More
2019-10-24 05:43
Metastasis is a major cause of death in cancer patients. According to the inverse relationship between migration and E-cadherin levels in vitro, it has been proposed that invasion and metast… Read More
2019-06-10 08:49
Induced pluripotent stem cells (iPS cells) can be transformed into any cells in the body or maintain their original form. In a new study, researchers from research institutions such as the H… Read More
2019-06-10 05:52
A team at Brown University found that Opsin3 is a protein closely related to rhodopsin, a protein that enables low-light vision. It regulates the amount of pigment produced in human skin, wh… Read More
2019-05-10 09:31
As we know, exosomes are small vesicles secreted by cells. Therefore, exosomes have the characteristics of donor cells and have certain cell specificity. In a large number of studies on exos… Read More
2019-05-10 09:25
In the early 1980s, researchers discovered exocytosis in normal cells or tumor cells cultured in vitro, and cells secreted vesicle structures with cell membrane characteristics in their cult… Read More
2019-04-04 09:20
In general, there are multiple pathways taken by cells to repair the same DNA damage, and the choice of repair pathway is important for maintaining genomic fidelity. Cross-linking between DN… Read More
2019-04-04 08:46
Protein post-translational modifications (PTM) include phosphorylation, methylation, acetylation etc. Protein expression is regulated by genomics and epigenetics, and after expression, it ne… Read More
2019-03-04 07:33
Transcription factors (TFs) are specific proteins that regulate gene expression, which can search for and bind specific regions in the entire genome to regulate gene expression. We all know… Read More
2019-03-04 04:14
Humans spend nearly a third of their time sleeping, but sleep is still one of the most enduring mysteries in biology. So far, scientists don’t know which genetic or molecular power is… Read More
2019-02-13 04:21
In a new study, researchers from Queen Mary College, University of London, UK, discovered that molecules released from invasive skin cancer reprogram the healthy immune cells to help spread… Read More
2019-02-12 09:45
In a new study, researchers from Johns Hopkins University in the United States found that as a special protein that cleaves other proteins, rhomboid proteases can break the “cell speed… Read More
2019-02-01 06:41
Recently, in a research report published in the international journal Nature Nanotechnology, scientists from McGill University have developed a new technology that can detect hundreds of pro… Read More
2019-02-01 02:07
Recently, research published in the Journal of Virology, scientists from the University of Minnesota developed a new strategy that is expected to block the spread of a highly infectious viru… Read More
2019-01-18 08:36
1.Science: Pro-Linked Protein 2 Cutting Can Prevent Heart Failure
doi:10.1126/science.aan3303; doi:10.1126/science.aav8956
Dr. Long-Sheng Song, a researcher at the University of Iowa in th… Read More
2019-01-14 08:38
Mutations in multiple genes are directly related to Parkinson’s disease, but researchers are not sure how these mutations affect individuals with Parkinson’s disease. A recent st… Read More
Embo Mol Med: Identification Of A Novel Therapeutic Target For The Chronic Inflammatory Colon Cancer
2019-01-12 08:11
Recently, a research report published in the international magazine EMBO Molecular Medicine, scientists from the Barcelona Institute of Biomedical Research discovered a new mechanism that ca… Read More
2019-01-10 07:12
In general, biosimilars are generic products of biopharmaceuticals. Different from generics, they are “similar” and therefore require approval procedures similar to new branded d… Read More
2019-01-10 04:06
Cells have many mechanisms to protect genomic integrity, including the process of repairing errors that may occur during DNA replication. The Dna2 nuclease is involved in DNA repair, but lit… Read More
2018-12-05 06:30
Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are malignant hematopoietic stem cell disorders, and abnormal stem cell populations in hematopoietic stem and progenitor cells… Read More
2018-12-04 07:00
Recently, scientists from the Dana-Farber Cancer Institute have discovered new drug targets for two malignant cancers. It is expected to develop new therapies for the treatment of synovial s… Read More
2018-11-19 08:21
Alzheimer’s disease is one of the most common forms of dementia. More than 30 million people worldwide suffer from Alzheimer’s disease. Unfortunately, there is currently no cure… Read More
2018-11-14 07:46
(…Continued)
JCI: Infectious HIV is not present in liver macrophages of HIV-infected patients receiving treatment
doi:10.1172/JCI121678
In a new study, researchers from Johns Hopki… Read More
2018-11-14 07:25
Human immunodeficiency virus (HIV), an AIDS (AIDS, acquired immunodeficiency syndrome) virus, is a virus that causes defects in the human immune system. In 1983, HIV was first discovered in… Read More
2018-11-07 06:52
Recently, researchers from the University of Kentucky found that targeting a protein called collagen XIII may effectively inhibit the metastasis of breast cancer. And the article relat… Read More
2018-11-07 05:50
CDK1 is a normal protein that drives cells through the replication cycle, while MHC class 1 molecule is also a normal molecule that exhibits a small amount of protein on the cell surface for… Read More
2018-10-16 06:33
For glioblastoma, immunotherapy faces a particular challenge—the blood-brain barrier blocks T cells from entering the brain to prevent brain inflammation that can be life-threatening… Read More
2018-10-16 01:50
Researcher Yao Hongjie from the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences published a research report entitled “PCGF5 is required for neural differenti… Read More
2018-09-12 07:15
Cancer cells are not just a group of cells that are out of control; for their own survival, they actively participate in the struggle with the immune system. Being able to evade detection by… Read More
2018-09-12 02:37
Recently, Zhou Rongbin and Jiang Wei, professors of the Department of Life and Medical Sciences of the University of Science and Technology of China, the Key Laboratory of Natural Immunology… Read More
2018-08-09 10:16
Johnson & Johnson recently announced that the company has stopped a clinical trial of a new Alzheimer’s disease drug due to certain safety issues. This is another failed clinical t… Read More
2018-08-09 08:27
Stimulatory dendritic cells (SDCs) play a key role in stimulating cytotoxic T lymphocytes and promoting immune responses against cancer. Studying the mechanisms that regulate the abundance o… Read More
2018-07-02 09:21
Due to the rapid development of antiretroviral therapy (ART), HIV patients can live longer than before. But even if it is a very effective long-term ART, the HIV virus remains stubbornly inc… Read More
2018-07-02 06:58
Multipoint phosphorylation of the PERIOD 2 (PER2) protein is a critical step in determining the mammalian clock cycle. Previous studies have suggested that the phosphorylation of PER2 by cas… Read More
2018-06-08 09:02
Over the past 3 million years, the evolution of larger brains has played an important role in our ability to think, solve problems, and develop cultures. However, it has always been a myster… Read More
2018-06-08 09:02
Over the past 3 million years, the evolution of larger brains has played an important role in our ability to think, solve problems, and develop cultures. However, it has always been a myster… Read More
2018-05-31 07:16
Recently, in a study published in Nature Medicine, researchers from Charite Medical College in Berlin successfully treated obese patients due to hereditary defects. The new drugs developed b… Read More
2018-05-31 03:06
Recently, in a study published in Nature, researchers from the University of Pennsylvania have found that the main features of different Parkinson‘s-related brain disorders may be intr… Read More
2018-05-08 08:02
(Continued)
Scientific Reports: New Computational Approach to Identify Chemotherapy Targets
(DOI: 10.1038/s41598-018-19284-3)
One of the most important features of tumors is the methylat… Read More
2018-05-08 07:14
Drug resistance is one of the main reasons leading to the failure of cancer treatment, which greatly limits the choice and use of cancer drugs, and breaking the hopes of the cancer patients… Read More
2018-05-03 09:45
Highlights
The oncogenic Gαs mutation R201C allows GDP-bound Gαs to activate adenylyl cyclase
GDP-bound Gαs(R201C/C237S) adopts an active state in its crystal structure… Read More
2018-03-29 04:26
If you are an immune cell ready to fight cancer, you’d better eat some breakfast. Because the tumor microenvironment is a harsh place, and tumor cells are always ready to make you exha… Read More
2018-03-28 08:39
A recent study published in Nature Communication reveals how cancerous cells differ from healthy ones, which paves way for the development of novel strategies for the therapeutic interventio… Read More
2018-03-26 03:18
(Continued)
4. Nat Commun: Latest research finds the key protein mechanism, which regulates heart and muscle
David Giganti et al, Disulfide isomerization reactions in titin immunoglobulin… Read More
2018-03-26 03:00
What we are bringing to you this time is recent advances in heart disease research and we hope it will be useful to you.
1. NEJM: Influenza increases the probability of heart attack by 6 ti… Read More
2018-03-15 05:38
Highlights
TBK1 operates at the intersection of energy expenditure and inflammation
TBK1 deficiency attenuates HFD-induced obesity but exaggerates inflammation
TBK1 represses energy expendit… Read More
2018-02-27 07:52
As we all know that the human body can function adaptively as the day and night change. And according to a new research from the Perelman School of Medicine at the University of Pennsylvania… Read More
2018-01-30 09:09
Recently an international team led by Professor Savvas Savvides at the VIB-UGent Inflammatory Research Center revealed the key molecular mechanisms of autoimmune and inflammatory diseases in… Read More
2018-01-30 08:55
Current research shows that women live longer than men. And a recent study found baby girls are more likely to survive in famine, epidemics and other unfortunate circumstances, why this hap… Read More
2018-01-29 06:23
In a recent study published in the Journal of Experimental Medicine, researchers from Caroline College and other institutions studied mice to elucidate the molecular mechanism of conversion… Read More
2018-01-23 07:34
In a recent study published in the journal Cancer Cell, researchers from Columbia University Medical Center found that stress may accelerate the development of pancreatic cancer by stimulati… Read More
2018-01-03 06:24
Most tumor growing can stop after long-time medicine intake, and even it can become smaller or finally disappear. But what made the doctors struggling was that a few months later cancer cell… Read More
2017-12-26 04:27
Continued
6. Nature’s New Discovery: Another Unidentified Anti-cancer Approach of PD-1 / PD-L1 Antibodies
doi: 10.1038/nature22396.
On May 17, Nature published an online article tit… Read More
2017-12-21 08:14
PD-1 (programmed cell death protein 1), the programmed death receptor 1, is an important immunosuppressive molecule. Immunomodulation which targets PD-1 is of great importance to anti-tumor… Read More
2017-12-01 06:02
(Continued)
9. Draw a four-dimensional map of the self-folding of the human genome
Suhas S.P. Rao, Su-Chen Huang, Brian Glenn St Hilaire et al. Cohesin Loss Eliminates All Loop Domai… Read More
2017-12-01 05:35
(Continued)
5. On average, one to ten mutations are sufficient to promote cancer
Iñigo Martincorena, Keiran M. Raine, Moritz Gerstung et al. Universal Patterns of Selection in… Read More
2017-12-01 03:28
There are lots of great articles published on Cell in October, let’s share some highlights for you.
1. New discovery on cancer metabolic which challenge the view of nearly 100 y… Read More
2017-12-01 02:46
Dr. Shi-Liang Hsieh and his team, from Genomics Research Center, Academia Sinica, has done years of work to find answers to inflammations. Recently, his team has confirmed that inflammation… Read More
2017-10-31 07:13
The Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank, and Richard Henderson for their development of Cryo-Electron Microscopy (cryo-EM), which simplified and imp… Read More
2017-10-25 04:14
2017/10/02, the 2017 Nobel Prize in Physiology or Medicine jointly to Jeffrey C. Hall, Michael Rosbash and Michael W. Young for their discoveries of molecular mechanisms controlling the circ… Read More
2017-10-17 08:57
According to the World Health Organization (WHO) statistics, in 2016, a total of about 36 million people suffering from human immunodeficiency disease in the world. Faced such a dilemma, in… Read More
2017-09-28 09:59
Recent study reveals: the number of deaths among children under five is decreasing. Though overall both men and women around the world are living longer, one in five deaths were linked to po… Read More
2017-09-25 02:27
Tau protein abnormal deposit is one of the most important characteristics for Alzheimer. Recently, a new finding published in Nature obtained high-resolution images of those protein deposit… Read More
2017-09-05 08:45
ABP215 is a biosimilar drug developed by Amgen and Allergan, using Avastin (bevacizumab) as a prototype drug. Amgen filed a drug application to the FDA in November 2016. The FDA Oncologic Dr… Read More
2017-07-29 04:29
Bill Gates said in a speech at the Munich Security Conference that three threats are closely related to the fate of our human species: nuclear warfare, climate change and the next global pan… Read More
2017-06-21 03:24
In a recent study published in Human Molecular Genetics, researchers from the University of Uppsala, found that tea consumption may lead to DNA methylation changes of some special genes in w… Read More
2017-06-09 10:20
According to the report of Grand View Research, the demand for recombinant technology, pharmaceutical biotechnology and DNA sequencing technology is increasing based on disease diagnosis and… Read More
2017-05-23 10:08
The vasculature is the earliest organ to develop. Unlike other organs it has to be functional throughout development and therefore has to constantly adapt to the changing requirements of emb… Read More
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