Multiple new medications for a variety of medical conditions were given the go light by the FDA in 2024. New medications with a wide range of indications have been brought to the pipeline th… Read More
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BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
What are the gene therapies?
Following Stanfield Rogers’s 1970 discovery of using “good†deoxyribonucleic acid (DNA) to replace fau… Read More
History of drugs for weight loss
In 1760, English physician Malcolm Flemyng was the first to refer to obesity as a disease. The public’s view of obesity could shift if… Read More
What are oligonucleotides?
Oligonucleotides, which cover both deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are increasingly demonstrating their central value in clinical pract… Read More
These protocols are for general guidance only. For specific protocols, please refer to the product description page of the corresponding ELISA kit.
Sandwich assay procedure
An appropri… Read More
When using engineered bacteria or cells to express foreign proteins, in order to obtain high-purity proteins more quickly and reduce downstream purification pressure, it is often necessary t… Read More
What is SDS-PAGE electrophoresis?
SDS-PAGE electrophoresis, short for sodium dodecyl sulfate polyacrylamide gel electrophoresis, is a kind of commonly used protein extraction technology t… Read More
Ethylene Diamine Tetraacetic Acid (EDTA) is an important complex agent. EDTA has a wide range of uses, can be used as a bleaching fixing solution for color sensitive materials washing proces… Read More
For a long time, the poor solubility and low bioavailability of APIhave been a major problem for drug developers, and the low solubility has led to the limitation of its formulation developm… Read More
PCR additives play a crucial role in the PCR process, acting on various stages of the PCR reaction through different mechanisms, affecting amplification efficiency, specificity, and yield. T… Read More
Targeted Chimera Proteolysis (PROTAC) technology represents a breakthrough development in the field of drug discovery, utilizing the ubiquitin proteasome system to specifically degrade… Read More
Vaccines are one of the most important inventions in human history, which has revolutionized human life and health. Typically, vaccines work by triggering an innate immune response and stimu… Read More
In the first half of the year, the FDA approved a number of landmark drugs, and there are many highlights:
Rezdiffra, the first non-alcoholic steatohepatitis drug in 40 years, was approve… Read More
In the development of immunoassay reagents, buffer is typically the second most critical factor after core materials. It can affect various fundamental properties of the reagents, such as st… Read More
The buffering capacity of HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer solution derives from its chemical structure and acid-base equilibrium properties. Specifical… Read More
A disaccharide is an elementary form of carbohydrate that is necessary for the intricate web of metabolic processes that keep life alive. These molecules constitute the combination of two mo… Read More
Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalen… Read More
The target spectrum and treatable diseases of small nucleic acid drugs are diverse. Relevant companies primarily focus on rare monogenic diseases with clear pathogenic mechanisms, well-defin… Read More
Molecular Glue refers to small molecules, typically smaller than PROTACs, often with improved physicochemical properties, designed to stabilize interactions between two proteins. In mos… Read More
In the process of small molecule drug development, lipophilicity (or hydrophobicity) is a very important indicator that has a crucial impact on pharmacokinetics and pharmacodynamics. Lipophi… Read More
mRNA therapeutics is a newly emerging form in recent years. Its basic principle is to introduce mRNA expressing antigen targets into the body through specific delivery systems, express prote… Read More
Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in ce… Read More
The preparation of amides is one of the most common reactions in organic synthesis and a key reaction for the preparation of peptide drugs and nucleic acid drugs in recent years. The re… Read More
The Drug-to-Antibody Ratio (DAR) is the most important quality attribute of ADC drugs because it determines the “payload” that can be delivered to tumors, directly impacting safe… Read More
In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of function… Read More
Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as me… Read More
What is Biotin?
Biotin, with a molecular weight of 244.31, consists of two cyclic structures. The first ring is the imidazolone ring, the primary site for binding with avidin; the second… Read More
In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successive… Read More
There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely… Read More
The popularity of thiol coupling in ADC preparation can be attributed to three factors:
thiol is the most nucleophilic functional group among amino acid side chains (much stronger than am… Read More
Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University… Read More
With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein… Read More
Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applicatio… Read More
4-1BB (CD137, TNFRSF9) is a crucial co-stimulatory receptor on T cells, discovered in 1989. In 1997, scientists at BMS published in Nature Medicine, demonstrating that the 4-1BB monoclo… Read More
Diabetes is a common clinical disease, and with the improvement of living standards, an increase in the number of obese people, and the intensification of aging populations, the incidence of… Read More
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and n… Read More
Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding abi… Read More
Influenza is an acute and highly contagious respiratory disease caused by influenza A and B viruses. Annual influenza epidemics are caused by several different seasonal influenza viruse… Read More
Brief Description of mRNA Delivery Systems
As a therapeutic use, mRNA cancer vaccines have the advantages of high safety, strong immune activation ability, and short production cycle. Mor… Read More
In recent years, antibody therapies (including traditional antibodies and nano-antibodies) have become an important means of treating a wide range of human malignant diseases, and more than… Read More
FDA approved the marketing of 14 drugs in the third quarter of 2023, including 6 small molecule drugs. This article mainly focuses on the drug design ideas of small molecule drugs… Read More
What is Adjuvants?
Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type o… Read More
Antibody conjugated drug (ADC) is a relatively complex molecule that connects a targeted antibody with a cytotoxic payload through a chemical linker. In recent years, peo… Read More
RNA-based therapeutics
The Human Genome Project (HGP) has revealed a wealth of information about the human genome and has greatly enhanced its role in the development of biomedical resear… Read More
In recent years, small nucleic acid drugs have emerged as a focal point in biomedical research due to their strong specificity, simple design, short development cycles, and diverse target op… Read More
In recent years, rapid advancements in gene therapy have brought about a significant transformation in modern medicine. The application of advanced molecular biology techniques and enhanced… Read More
With the rise of genomics and proteomics, many clinically significant targets have been discovered in human diseases. However, a relatively small proportion of traditional druggable targets… Read More
Antibody drug conjugates (ADCs) are multi-domain molecules composed of monoclonal antibodies, linkers and small molecule cytotoxins. ADCs specifically bind target antigens hig… Read More
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC d… Read More
At the 5th United Nations Environment Assembly (UNEA-5) held in March 2022, 175 countries signed a resolution to end plastic pollution. The aim is to achieve a legally binding internati… Read More
Breast cancer is the leading cause of death among women worldwide. When breast cancer spreads to other parts of the body, the prognosis is poor. Currently, there is no treatment for metastat… Read More
