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BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
What Is HEPES Buffer Solution?
The buffering capacity of HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) buffer solution derives from its chemical structure and acid-base equilibrium properties. Specifical… Read More
What Is Disaccharide?
A disaccharide is an elementary form of carbohydrate that is necessary for the intricate web of metabolic processes that keep life alive. These molecules constitute the combination of two mo… Read More
What Is Reversible Inhibitor?
Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalen… Read More
Lipophilicity Of Drug
In the process of small molecule drug development, lipophilicity (or hydrophobicity) is a very important indicator that has a crucial impact on pharmacokinetics and pharmacodynamics. Lipophi… Read More
MRNA Purification Methods
mRNA therapeutics is a newly emerging form in recent years. Its basic principle is to introduce mRNA expressing antigen targets into the body through specific delivery systems, express prote… Read More
New PROTAC Technology
Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in ce… Read More
RNA-targeted Gene Therapy
In the early 21st century, after the completion of the Human Genome Project, it was discovered that many diseases were caused by gene mutations leading to insufficient expression of function… Read More
The Magical Biotin
What is Biotin? Biotin, with a molecular weight of 244.31, consists of two cyclic structures. The first ring is the imidazolone ring, the primary site for binding with avidin; the second… Read More
Preparation Methods Of Microspheres
There are various techniques for the preparation of microspheres, and the selection of an appropriate method depends on the physicochemical properties of the drug. Currently, the most widely… Read More
Several Ways Of Thiol Coupling In ADCs
The popularity of thiol coupling in ADC preparation can be attributed to three factors: thiol is the most nucleophilic functional group among amino acid side chains (much stronger than am… Read More
What Is Peptide Nucleic Acid (PNA)?
Peptide Nucleic Acid (PNA) is a synthetic polymer similar to DNA or RNA. PNA can be said to have been born in Denmark, where it was originally developed by Peter E. Nielsen (University… Read More
General Design Methods For MRNA Drugs
With the rapid development of biotechnology and molecular medicine, the introduction of mRNA as a vaccine or therapeutic agent enables the production of almost any desired functional protein… Read More
Paclitaxel is a natural anticancer drug with the molecular formula C47H51NO14. It has been widely used in the clinical treatment of breast cancer, ovarian cancer, and certain head and n… Read More
Review Of Popular Targets
In recent years, antibody therapies (including traditional antibodies and nano-antibodies) have become an important means of treating a wide range of human malignant diseases, and more than… Read More
CMC Regulatory Considerations For ADCs
Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC d… Read More
PEG-Lipid: Structure And Properties
PEG-Lipid derivatives have the advantages of increasing the stability of liposomes, extending the half-life of blood circulation, improving tumor targeting efficiency and enhancing drug… Read More
Natural Products Research Update
This article covers the latest developments in natural product research, primarily including ribosomally synthesized peptides, sesquiterpenes, diterpenes, and triterpenes. 1. Di… Read More
Research Progress Of Dual-Loading ADCs
Antibody-drug conjugate (ADC) combines the tumor targeting specificity of monoclonal antibodies and the potent cell killing activity of cytotoxic drugs (warhead/payload), through a care… Read More
Deuterated Drugs Research Progress
What are Deuterated Drugs? Deuterated drugs are medications obtained by substituting hydrogen atoms at specific positions on drug molecules with deuterium atoms. The most w… Read More
Circular RNA Synthesis
The Background of Circular RNA Synthesis In recent years, nucleic acid therapy involving various types of ribonucleic acids (RNAs), including messenger RNA (mRNA), small interfering RNA (… Read More
Optimization Of SiRNA Design
The length of siRNA is 7-8 nm, the diameter is 2-3 nm, the molecular weight is 13-14 kDa, and it is hydrophilic. Therefore, unmodified and naked siRNA cannot passively cross the cell membran… Read More
Nectin-4: A New Target Of ADC
Overview of Nectin Nectin, a cell adhesion molecule belonging to the Immunoglobulin (Ig) superfamily, is a homologue of poliovirus receptor (PVR/CD155). It also known as poliovirus r… Read More
Overview of Peptide-drug Conjugate
The concept of drug conjugates originated in the early 20th century. In 1910, Paul Ehrlich proposed the “Magic Bullet” theory, which aimed to describe the concept of a drug that… Read More
Emerging ADC Targets: B7-H3 And B7-H4
B7-H3 and B7-H4 are type I transmembrane proteins belonging to the B7 family. Their abnormal expression is associated with many diseases such as colon cancer, breast cancer, liver cancer, an… Read More
List Of ADCs Targeting HER
Introduction to HER and ADCs Members of the human epidermal growth factor receptor (HER) family, including HER1 (EGFR), HER2, HER3, and HER4, play a core role in regulating cell prolifera… Read More
Mechanisms Of Tumor Immunity
Mechanisms of Immune Escape in Tumors Although the human immune system uses powerful immune cells and various immune measures, some immunogenic tumors evade clearance after initially bein… Read More
Methods Of Nucleoside Bond Formation
Nucleic acid is a biopolymer compound composed of nucleotides and is one of life’s basic substances. It is widely found in all animal and plant cells, microorganisms, and organisms, an… Read More
How To Make MRNA Vaccines In 18 Steps
The launch of two mRNA vaccines in 2020 marked the formal entry of mRNA technology into the commercial era. Strong vaccine demand is expected to bring bright prospects to the entire ind… Read More
MRNA Drugs: Pros, Cons, And Prospects
Globally, the COVID-19 pandemic has significantly accelerated the development of mRNA technology platforms and mRNA industry chains. The first mRNA drug (BNT162b2 vaccine) was granted emerge… Read More
Genotoxic impurities can directly act on DNA in the human body, causing DNA damage and having carcinogenic, teratogenic, or mutagenic properties. A small amount of genotoxic impurities… Read More
The analysis of impurities in drugs is a very important part. This blog focuses on the important role of the source analysis of impurities and the development of analytical te… Read More

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BOC Sciences Blog