Practical Uses for Quantum Computers In the rapidly evolving field of quantum computing, practical applications are beginning to surface, particularly in the realm of chemistry. These advanc… Read More

Covalent inhibitors generally refer to irreversible covalent inhibitors; however, in detailed studies, they can be divided into irreversible covalent inhibitors (ICIs) and reversible covalen… Read More

Protein homeostasis refers to the balance of proteins within cells, involving processes such as protein synthesis, folding, modification, transport, function, and degradation. Proteins in ce… Read More

Driven by increasingly mature technologies, ADC payloads have undergone three generations of innovation. In the first generation of ADC drugs, traditional chemotherapy agents such as me… Read More

Thrombin is a crucial enzyme involved in the coagulation cascade and formation of blood clots. Inhibiting the activity of thrombin has emerged as an important strategy for anticoagulation t… Read More

New Delhi: The Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) has approved the drug major Novartis protocol amendment proposal for cli… Read More

Chemical drugs can be classified into three categories based on their binding modes: covalent drugs, non-covalent drugs, and covalent reversible drugs. Covalent drugs have strong binding abi… Read More

Most Common Site For Breast Cancer Metastasis – Metastatic breast cancer, also called metastases, advanced breast cancer, secondary tumors, secondary or stage IV breast cancer, is the… Read More

With the rise of genomics and proteomics, many clinically significant targets have been discovered in human diseases. However, a relatively small proportion of traditional druggable targets… Read More

Among the first-generation ADC drugs, traditional chemotherapy drugs such as methotrexate, vinblastine, and doxorubicin were used as cytotoxic payloads. However, due to insufficient cyt… Read More

What are enzymes? Enzymes are peculiar proteins essential in furthering and encouraging biochemical reactions in living organisms. The catalyst characteristics of enzymes speed up the pro… Read More

Covalent drugs refer to those drug molecules that form strong bonds with receptors through the formation of covalent bonds. It all began with aspirin in 1899, gained prominence with ibr… Read More

In recent years, PROteolysis TArgeting Chimeras (PROTAC), which utilizes the cell’s own degradation mechanisms to eliminate specific disease-related proteins, has emerged as one of the… Read More

What Is The Role Of Enzymes In The Human Body – ). Its main function is to act as a catalyst to speed up a reaction without itself being changed in the process. Enzymes are generally p… Read More

What Is The Role Of Enzymes In Chemical Reactions – )’s main function is to act as a catalyst to speed up a reaction without changing itself in the process. Enzymes are usually p… Read More

Janus kinases (JAKs) belong to the non-receptor tyrosine kinase family, and their JAK-STAT signaling pathway with signal transducers and activators of transcription (STAT) can affect cell pr… Read More

Introduction Antineoplastic drugs, also known as anticancer or chemotherapy drugs, are a class of medications used in the treatment of cancer. They are designed to inhibit or destroy cancer… Read More

Zacks recently released a research report covering Lexaria Bioscience, a global innovator in drug delivery platforms The report discusses the company’s ongoing research and de… Read More

Introduction Enzyme activity is regulated by a variety of mechanisms, including: Substrate availability: The concentration of substrate molecules can affect the rate of enzyme-catalyzed reac… Read More

Targeted protein degradation (TPD) technology has been developed rapidly in recent years, especially proteolysis targeting chimeras (PROTACs). To date, a large number of degraders have been… Read More

In late 2014, the PARP inhibitor Olaparib was approved to treat ovarian cancer with BRCA mutations. Since then, research in the field of PARP has received extensive attention, especially in… Read More

Loxo Oncology (Eli Lilly and Company) recently announced that their Bruton tyrosine kinase inhibitor (BTKi), Jaypirca (pirtobrutinib), was approved by the US Food and Drug Administration (FD… Read More

Enzymes Kinetics - RPSC FSOWhat is Enzymes Kinetics?Enzyme kinetics is the study of the chemical reactions that are catalyzed by enzymes, as well as the factors that affect these reacti… Read More

 PROTEINS: FUNCTIONS & CLASSIFICATIONWHAT ARE PROTEINS?The word "Protein" was coined by J.J. Berzelius in 1838 and was derived from the Greek word "Proteios" meaning the ‘firs… Read More

Despite recent advances in the systemic treatment of gastroesophageal cancers, prognosis remains poor. Comprehensive molecular analyses have characterized the genomic landscape of gastroesop… Read More

Mutations in the epidermal growth factor receptor (EGFR) kinase domain are the oncogenic drivers of this adenocarcinoma. Tyrosine kinase inhibitors (TKIs), developed over the last two decade… Read More

Proteasome is the main pathway by which misfolded proteins and other proteins are proteolyzed during protein synthesis. It is found in all eukaryotic cells, archaea and some bacteria and is… Read More

FSc Biology Part 1 XI 11th Chapter 3 Enzymes Notes Long QuestionsIf you want to see other Biology Part 1 MCQs, Short Questions & Notes Click Here.EnzymesEnzymes are the most im… Read More

PD-1 inhibitors restore the activity of tumor-responsive CD8 + T cells by eliminating the inhibition induced by PD-1 and PD-L1 interaction. This therapy has brought great changes to cancer t… Read More

The magnetic beads (MBs) technology is a burgeoning method that uses modified magnetic microspheres as carriers for targeted capture and enrichment. The key point of this technology is… Read More

The growth in epigenetics market is primarily attributed to decreasing sequencing costs, increasing research activity, funding for epigenetics research, rising prevalence of cancer and growi… Read More

What is enzyme? Enzymes are biological molecules (mainly proteins) produced by a living organism which act as catalysts in the body. It increases the rate of any chemical or biochemical r… Read More

INDIANAPOLIS and STAMFORD, Conn. -- Eli Lilly and Company (NYSE: LLY) and Loxo Oncology, Inc. (NASDAQ: LOXO) today announced a definitive agreement for Lilly to acquire Loxo Oncology for $23… Read More