Malaria affects more than 200 million people worldwide every year, and resistance to antimalarial treatments is constantly increasing. This infectious disease is caused by Plasmodium parasites that are capable of adapting to varied environments. During the parasite's life cycle, it lives in the salivary glands of the mosquito vector before infecting the liver and then the blood of the human host.
Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes. The parasites manage to acclimatize to these two completely different hosts because the plasticity of their genome enables them to adapt as necessary.
Scientists decided to investigate the epigenetic mechanisms behind this plasticity, in particular Dna Methylation. They identified molecules capable of inhibiting DNA methylation and effectively killing even the most resistant Plasmodium falciparumparasites.
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Posted by Dr. Tim Sandle, Pharmaceutical Microbiology Resources (http://www.pharmamicroresources.com/)
