Introduction from Drug Peptide supply about:Caerulein/17650-98-5

Introduction of Caerulein

Caerulein is the skin extract of the Australian frog HYlaCaerulea. It is composed of 10 amino acids. It is a cholecystokinin analog, which acts on pancreatic acinar cells and can cause the secretion of a large amount of digestive enzymes and pancreatic juice, resulting in Acute Edematous Pancreatitis. Cerulein can be used to study signal transduction pathways mediated by NF-κB up-regulated proteins such as intercellular adhesion molecule (ICAM-1), inflammation-related factors such as NADPH oxidase, and Janus kinase. It has been successfully used in the establishment of acute pancreatitis (AP) models in rats, mice, dogs and Syrian hamsters. It can be administered by intravenous injection, subcutaneous injection or intraperitoneal injection, and intravenous injection is the best. It has been widely used in the modeling of acute edematous pancreatitis in animal experiments and in cell models in vitro. It can also be used to check gallbladder function.

Application of Caerulein

1. It has been widely used in the modeling of acute edematous pancreatitis in animal experiments.
2. In vitro experiments applied to cell models.
3. For the examination of gallbladder function.
4.Caerulein cerulein (cerulein) method to establish a model for the study of acute pancreatitis (AP) cell biology and pathophysiological characteristics and to study systemic disease manifestations. In addition to investigating changes in the lung aspects of AP disease, it is useful to elucidate visceral endocrine interactions such as activin and CCK levels. It can also be used to assess the healing and repair of injured tissue after cessation of toxic substances.
5. Combined use of Caerulein (cerulein) and LPS to establish a pancreatitis model can have a synergistic effect. The former stimulates pancreatic juice enzymes to destroy the pancreas and continuously activates inflammatory cells to release inflammatory factors. Subsequently, LPS destroys the normal response of inflammatory mediators, and further develops localized pancreatitis as a systemic severe inflammatory response.
6. Cerucin can be used to prevent gallbladder pain, renal colic and intermittent claudication pain. It is generally considered to be an antagonist of endorphins.

How to buy Caerulein in the U. S.

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