Me, Natalie was Al Pacino's film debut in a minor supporting role as Tony. The film directed by Fred Coe, and the screenplay written by A. Martin Zweiback, based on original story by Stanley Shapiro. The film stars Patty Duke as Natalie Miller, Elsa Lanchester as Miss Dennison, and James Farentino as David Harris.

Natalie Miller was a plain and ugly Brooklyn young girl with bucked teeth and disproportionate large nose. Her father even had plan to bribes a myopic man to marry her, think that his nearsightedness will prevent him from seeing her ugly duckling appearance.

Natalie leaves home, seeking for her independence by start a bohemian lifestyle in Greenwich Village after she discovers her father's plan. After passing some miserable life journey and a heartbreak moment, Natalie finally found her self-esteem, realize that she's invaluable, just like everyone else.

Me, Natalie receive generally positive reviews. Patty Duke won Golden Globe Award for Best Actress - Motion Picture Musical or Comedy for her role as Natalie Miller. The film also receive Grammy Award nomination for Best Original Score Written for a Motion Picture or Television Show, as well as nomination for Best Drama Written Directly for the Screen from Writers Guild of America.

Two years after made brief screen appearance in this independent movie, Al Pacino made his next screen appearance in 1971 film The Panic in Needle Park.