The Hennessey Venom F5 is a high-performance sports car manufactured by Texas-based Hennessey Special Vehicles, a division of Hennessey Performance Engineering. This car is the first completely in-house developed and constructed vehicle from the tuner company including the chassis, body work, engine and exhaust system developed by the company along with other bespoke componenets.

The car's F5 name is a reference to the F5 tornado, the fastest in the Fujita scale, reaching as high as 300 mph (483 km/h).

The Hennessey Venom F5 was unveiled at the SEMA Show in Las Vegas, Nevada, on November 1, 2017, with high expectations of its intended world-beating speed record. Using its projected 2.0 second 0–60 mph (0–97 km/h) acceleration and projected 301 mph (484 km/h) top speed, Hennessey’s Venom F5 aims to eliminate the Bugatti Chiron and the Koenigsegg Agera on all acceleration and speed factors.

The price of the car in the United States will be US$1.6 million, and GB£1.2 million in Europe with the planned production of only 24 units. The owners of the car will only be hand-picked, in lieu of "first come, first serve" basis.