So in addition to reformatting friends and relatives computers, about every 2 years I clean out my own. Each time I have, I’ve lost my Notepad++ FTP synchronize settings.

In Vista they can be found in:
C:\Users\AppData\Roaming\Notepad++\plugins\config\FTP_synchronize.ini

Copy them to Backup and replace. In case an update gets hosed, or you are re-installing.