this paper econometrically examined the impact of Manufacturing Sector on economic growth in Nigeria from the period 1981 to 2015 using ordinary least square method. based on the major findings, it was concluded that a significant positive relationship exist between manufacturing output and economic growth in Nigeria. However, the most profound of the hazards faced in manufacturing sector are physical hazard, chemical hazard and psychosocial hazard as revealed by the mean score result. it is therefore pertinent to suggest that employers should improve the dissemination of information to worker on safety matters in order to remind them of the importance of following the safety measures for achieving a safety workplace. the government should intensify effort at improving physical infrastructure notably in the area of power supply and make it more accessible to manufacturers in order to reduce self-supply of electricity which brings huge operating cost.