Andie MacDowell is moving her ageless face to a new crib -- the longtime L'Orealspokeswoman is selling her Asheville, North Carolina estate ... for $4.5 million.

The 10,872 square foot Tudor-style home has 6 bedrooms, 8 bathrooms, a game room, and a 2,207 square foot fully-finished basement.

On top of all the space -- the home overlooks the seventh hole fairway of a ritzy golf course and country club.