A large study of 80,000 Migraine sufferers has discovered potential new ways of treating migraines. The study, led by deCODE Genetics in Iceland, analyzed genetic data from over 1.3 million participants and focused on detecting sequence variants associated with two main subtypes of migraines: migraine with aura and migraine without aura. The results identified several genes that affect one subtype over the other, pointing to new biological pathways that could be targeted for therapeutic developments. The study also discovered associations with 44 variants, 12 of which are new, and identified a rare variant in the KCNK5 gene that confers large protection against severe migraine and brain aneurysms.
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