John Mattick and Paulo Amaral have written a book that promotes their views on the content of the human genome. It will be available next August. Their main thesis is that the human genome is full of genes for regulatory RNAs and there's very little junk. A secondary theme is that some very smart scientists have been totally wrong about molecular biology and molecular evolution for the past fifty years.

I pretty much know what's going to be in the book [see John Mattick presents his view of genomes]. I also know that most of his claims don't stand up to close scrutiny but that's not going to prevent it from being touted as a true paradigm shift. (It's actually a paradigm shaft.) I suspect it's going to get favorable reviews in Science and Nature.

Here's how the publishers describe the book [RNA, the Epicenter of Genetic Information].

The origin story and emergence of molecular biology is muddled. The early triumphs in bacterial genetics and the complexity of animal and plant genomes complicate an intricate history. This book documents the many advances, as well as the prejudices and founder fallacies. It highlights the premature relegation of RNA to simply an intermediate between gene and protein, the underestimation of the amount of information required to program the development of multicellular organisms, and the dawning realization that RNA is the cornerstone of cell biology, development, brain function and probably evolution itself. Key personalities, their hubris as well as prescient predictions are richly illustrated with quotes, archival material, photographs, diagrams and references to bring the people, ideas and discoveries to life, from the conceptual cradles of molecular biology to the current revolution in the understanding of genetic information.

Some of the promotional blurbs are written by Tom Cech, Joan Steitz, and John Rinn. The blurb by Peter Vogt (below) is a fabulous endorsement. It's also a really good illustration of the true meaning of irony.

The book is unique. It provides the long-overdue correction of the still widespread static views on evolution, development and genome organization and function. It has the potential to induce radical changes in widely held views and attitudes.

I really hope someone will write that about my book when it's published.

What's really interesting is how closely the section titles resemble the ones in my book. I suspect the content of those sections will be quite different. Here's an example ...

Chapter 7 All that junk

• The C-value enigma
• Duplication and transposition
• Mutational load, nonsense DNA, nonsense RNA
• Neutral evolution
• Conservation and selection
• Junk DNA
• Selfish DNA
• Genes-in-pieces!
• Not junk?

Here are some recent posts about John Mattick.

• The biggest mistake in the history of molecular biology (not!)
• John Mattick's latest attack on junk DNA
• How much of the human genome is devoted to regulation?
• John Mattick still claims that most lncRNAs are functional
• John Mattick vs. Jonathan Wells
• The Junk DNA Controversy: John Mattick Defends Design
• The Dark Matter Rises
• How Not to Do Science /li>
• John Mattick on the Importance of Non-coding RNA
• John Mattick Wins Chen Award for Distinguished Academic Achievement in Human Genetic and Genomic Research
• International team cracks mammalian gene control code
• Greg Laden Gets Suckered by John Mattick
• How Much Junk in the Human Genome?
• Genome Size, Complexity, and the C-Value Paradox