The Best Crypto Gambling Sites for the USA I made this section separate specifically for US gamblers because it’s particularly difficult to gamble online from the US. If you’re not residing in the US, feel free to skip this section. There aren’t many online gambling sites accepting US players, not to mention crypto gambling sites accepting US players … Your best option to gamble online with Bitcoin from the US is BetOnline.  BetOnline has been in business for a very long time (since 2004). They have good offers for casino, sports betting, esports betting and online poker players.  And of course, they accept Bitcoin and more cryptocurrencies.