OVERVIEW:

Transcriptional Activators are proteins that stimulate Transcription of nearby genes by binding to DNA. They turn on the gene expression in eukaryotic cell.

Activators such as DNA-binding proteins bind to enhancers that stimulates transcription at promoter region.

Activators increases Rna Polymerase binding to the open complex that is needed for initiation of transcription.

Mostly activators binds to a DNA sequence which is located in or near a promoter and makes protein–protein interactions with transcription machinery such as RNA polymerase and general transcription factors. It binds general transcription machinery to the promoter.

EXAMPLE:

Catabolite repression by cAMP-CRP

The catabolite activator protein( CAP) activates transcription at the lac operon by making protein–protein interaction with RNA polymerase and this helps the recruitment of RNA polymerase to the lac promoter.

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