| Date & Time | Favorite | Line | Underdog | Total |
| 9/15 8:25 ET | At Buffalo | PK | NY Jets | 40.5 |
| 9/18 1:00 ET | At Detroit | -5.5 | Tennessee | 47 |
| 9/18 1:00 ET | At Houston | -2.5 | Kansas City | 43.5 |
| 9/18 1:00 ET | At New England | -6.5 | Miami | 41.5 |
| 9/18 1:00 ET | Baltimore | -6.5 | At Cleveland | 43 |
| 9/18 1:00 ET | At Pittsburgh | -3.5 | Cincinnati | 48.5 |
| 9/18 1:00 ET | At Washington | -3 | Dallas | 45.5 |
| 9/18 1:00 ET | At NY Giants | -5 | New Orleans | 52.5 |
| 9/18 1:00 ET | At Carolina | -13 | San Francisco | 45 |
| 9/18 4:05 ET | At Arizona | -6.5 | Tampa Bay | 50 |
| 9/18 4:05 ET | Seattle | -6 | At Los Angeles | Off |
| 9/18 4:25 ET | At Denver | -6 | Indianapolis | 45 |
| 9/18 4:25 ET | At Oakland | -5 | Atlanta | 49 |
| 9/18 4:25 ET | At San Diego | -3 | Jacksonville | 47.5 |
| 9/18 8:30 ET | Green Bay | -2 | At Minnesota | 44 |
| 9/19 8:35 ET | At Chicago | -3 | Philadelphia | 42.5 |
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