The 49ers selected cornerback Ambry Thomas out of Michigan with the 102nd pick of the NFL Draft. This pick was a compensatory pick for losing Emmanuel Sanders.

Thomas spent his first two years at Michigan in 2017 and 2018 as a backup, recording 16 tackles and one interception during the two years. Prior to the 2019 season he spent a month in the hospital after being diagnosed with colitis. After believing he’d have to sit out the year due to the condition, Thomas returned and he became a starter for the first time. He started all 13 games and had 38 tackles and three interceptions that season. Thomas opted out of the 2020 season and entered the 2021 NFL Draft.