Wil Myers hit a grand slam and former Ranger Jurickson Profar added a two-run homer to lead San Diego to a win at Arlington, Texas.
Kyle Lewis scored on a groundout in the seventh inning and Marco Gonzales matched a career high with nine strikeouts for the reeling Mariners, who have lost seven consecutive games.
Tim Anderson, Yoan Moncada and Jose Abreu combined to go 8-for-12 with a home run and eight RBIs as the top of the order powered host Chicago past Detroit.
Josh Bell hit a two-run double and Colin Moran an RBI single for the Pirates, who had played just two games in eight days because of COVID-19 concerns with their scheduled opponents.
Mike Yastrzemski and Pablo Sandoval homered, Trevor Cahill and five relievers combined on a five-hitter and San Francisco beat Los Angeles in Anaheim, Calif.
Caleb Baragar, Sam Selman, Wandy Peralta, Jarlin Garcia (1-1) and Shaun Anderson combined to hold the Angels to one run and one hit over the final five innings to close it out.
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