Drinkwater was an unused substitute against his former club Leicester last Saturday and missed the midweek Champions League Win over Qarabag with a calf problem which means he could be out for four weeks.
Provisional squad: Courtois, Caballero, Rudiger, Alonso, Fabregas, Kante, Morata, Hazard, Pedro, Bakayoko, Moses, Kenedy, Musonda, Zappacosta, Willian, Batshuayi, Cahill, Christensen, Azpilicueta, Luiz, Clarke-Salter, Scott, Eduardo.
Manager Arsene Wenger made nine alterations for the Europa League win over Cologne but the likes of Petr Cech, Mesut Ozil, Laurent Koscielny and Alexandre Lacazette will all return to the squad at Stamford Bridge.
Provisional squad: Cech, Ospina, Mertesacker, Holding, Koscielny, Monreal, Mustafi, Bellerin, Nelson, Kolasinac, Ramsey, Wilshere, Coquelin, Xhaka, Elneny, Ozil, Giroud, Walcott, Sanchez, Iwobi, Welbeck, Lacazette.
The Gunners have won only two such games out of 21 since the start of the 2013-14 season, with their last victory coming at Manchester City in January 2015 - since when their record shows five draws and eight defeats, including their current five-game losing run.
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