The heavy defeat consigned the Hammers to the bottom of the table, with summer signings Javier Hernandez, Marko Arnautovic, Pablo Zabaleta and Joe Hart unable to stem the tide at Old Trafford.
But with two more away fixtures before they play at the London Stadium again following the World Athletics Championships, the Hammers must improve on the road as they face Manuel Pellegrino's Saints at St Mary's.
Southampton: Forster, Cedric, Stephens, Yoshida, Bertrand, Romeu, Lemina, Davis, Tadic, Redmond, Gabbiadini.
West Ham: Hart, Zabaleta, *Ogbonna, Fonte, Cresswell, Rice, Noble, Ayew, Antonio, Arnautovic, Hernandez.
Predicted West Ham XI: Hart; Zabaleta, Reid, Ogbonna; Antonio, Noble, Obiang, Cresswell; Arnautovic, Ayew, Hernandez
- Southampton v West Ham LIVE: Premier League updates and team news from St Mary'sDaily Star
- Southampton 0-0 West Ham live score and goal updates from Premier League clash ...Mirror.co.uk
- Javier Hernandez and Marko Arnautovic give West Ham an extra edge, says ...Evening Standard
- All the build-up, chat, team news and match action live from St Mary's as ...Daily Echo
- Stewart Robson blasts West Ham: Something is wrong, the club is not being run ...Express.co.uk
- David Sullivan, David Gold good for West Ham - Slaven BilicESPN FC
- Southampton v West Ham United LIVE stream and confirmed line-ups: talkSPORT 2 ...talkSPORT.com
- Team news: Antonio and Rice start at SouthamptonWest Ham United F.C. (press release) (registration)
- Southampton v West Ham - Team-SheetsVitalfootball