Estriol Vaginal Cream is a naturally occurring, potent form of estrogen and is the most abundant of the three major estrogens in women. It plays a critical role in female reproductive health, as it helps regulate various bodily functions such as menstruation, pregnancy, childbirth, and menopause. One of the most popular uses of estriol is in vaginal cream form ; this application helps relieve vaginal dryness and discomfort associated with menopause.