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Etoposide (Etopophos®, Toposar®, Vepesid®, VP-16)

Coverage Indications, Limitations, and/or Medical Necessity

Etoposide (Etopophos®, Toposar®, VePesid®, VP-16)-J9181

Etoposide is a podophyllotoxin which inhibits DNA synthesis prior to mitosis by blocking topoisomerase II.

Etoposide is FDA approved for the following indications:
  • Management of refractory testicular tumors, in combination with other approved chemotherapeutic agents.
  • In combination with other approved chemotherapeutic agents as first-line treatment in patients with small cell lung cancer.
Etoposide will be covered when provided for its FDA approved uses, as well as for the Treatment of the following off-labeled indications:
  • Primary peritoneal carcinoma
  • Fallopian tube carcinoma
  • Gastric carcinoma
  • Hepatoblastoma
  • Neuroblastoma
  • Non-small cell lung carcinoma
  • Testicular cancer
  • Thymoma
  • Osteosarcoma
  • Ewing’s sarcoma
  • Soft tissue sarcomas
  • Cutaneous T cell lymphomas
  • Breast carcinoma
  • AIDS associated Kaposi’s sarcoma
  • Endometrial carcinoma
  • Ovarian germ cell tumors
  • Bladder carcinoma
  • Wilms’ Tumor
  • Retinoblastoma
  • Adrenocortical carcinoma
  • Acute lymphocytic leukemia
  • Acute nonlymphocytic leukemia
  • Chronic myelocytic leukemia
  • Hodgkin’s lymphoma
  • Non-Hodgkin’s lymphoma
  • Multiple myeloma
  • Primary brain tumor
  • Gestational trophoblastic tumor
  • Cancer of Unknown Primary site (CUPs)
  • Trophoblastic neoplasm
  • Myelodysplastic syndromes (MDS)
  • Neuroendocrine tumors (malignant poorly differentiated)
  • For Merkel cell carcinoma in combination with carboplatin or cisplatin as a consideration for adjuvant treatment with or without radiation therapy for N+ disease
  • For Merkel cell carcinoma in combination with carboplatin or cisplatin as treatment for distant metastatic disease or disseminated recurrence with or without surgery or radiation therapy

CPT/HCPCS Codes

Group 1 Paragraph: N/A

Group 1 Codes:
CODE DESCRIPTION
J9181 INJECTION, ETOPOSIDE, 10 MG

References:
https://www.cms.gov/medicare-coverage-database/details/lcd-details.aspx?LCDId=33723&ver=15&DocType=2&bc=AAIAAAAAAAAA&


This post first appeared on Interventional Radiology Medical Coding - Learn How To Code, please read the originial post: here

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Etoposide (Etopophos®, Toposar®, Vepesid®, VP-16)

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