There is no one in the world who had not witnessed headaches at a point in life! Is there anyone?

So one might wonder which structures are responsible for headache.

Scientists have shown only a few structures are responsible for causing Pain in the head through various research. Most of the brain covering pia-arachnoid and dura over the convexity of the brain, the brain parenchyma, and the ependyma (ventricular lining) and choroid plexuses lack sensitivity to pain.

Here is the list of pain sensitive structure in cranium:

(1) Skin, subcutaneous tissue, muscles, extracranial arteries, and periosteum of the skull;

(2) Delicate structures of the eye, ear, nasal cavities, and paranasal sinuses;

(3) Intracranial venous sinuses and their large tributaries, especially pericavernous structures;

(4) Parts of the dura at the base of the brain and the arteries within the dura, particularly the proximal parts of the anterior and middle cerebral arteries and the intracranial segment of the internal carotid artery;

(5) The middle meningeal and superficial temporal arteries; and

(6) The optic, oculomotor, trigeminal, glossopharyngeal, vagus, and first three cervical nerves.