What is the elevation of GGT (Gamma Glutamyl Transferase)?

Gamma Glutamyl Transferase (GGT) is an enzyme that is found in various tissues of the human body, including the liver, pancreas, and kidneys. It is primarily involved in the metabolism of glutathione, a powerful antioxidant that helps to protect cells from oxidative damage. GGT is also involved in the transport of amino acids across cell membranes, and it plays a role in the regulation of cellular growth and differentiation.

One of the most important clinical uses of GGT is as a marker of liver function. Elevated levels of GGT in the blood are often indicative of liver damage or disease, and can be used to diagnose conditions such as hepatitis, cirrhosis, and liver cancer. GGT levels can also be elevated in cases of alcohol abuse, as alcohol is known to damage liver cells and increase GGT production.

The normal range for GGT levels in the blood varies depending on the laboratory and the method of analysis used. In general, however, normal levels of GGT are considered to be less than 45 U/L for men and less than 30 U/L for women. Elevated levels of GGT are typically defined as being greater than 60 U/L for men and greater than 45 U/L for women.

There are several factors that can influence GGT levels in the blood. These include age, sex, body mass index (BMI), and certain medications and supplements. For example, GGT levels tend to increase with age, and are generally higher in men than in women. Obesity and diabetes can also lead to elevated GGT levels, as can the use of certain medications such as phenytoin, carbamazepine, and rifampin.

In addition to its role as a marker of liver function, GGT has also been implicated in a number of other health conditions. For example, elevated GGT levels have been associated with an increased risk of cardiovascular disease, diabetes, and metabolic syndrome. Some studies have also suggested that GGT may be a marker of oxidative stress and inflammation, both of which are thought to play a role in the development of many chronic diseases.

Despite its importance in clinical practice, there is still much that is not known about GGT and its role in human health. Further research is needed to better understand the mechanisms by which GGT influences disease risk, and to develop new treatments and interventions that can help to reduce GGT levels and improve health outcomes.