- The JELIS- The Japan EPA Lipid Intervention Study randomized 18645 patients with hypercholesterolemia (of which 70% were women: age 61 years) to statin alone or statin and pure EPA. EPA reduced major adverse cardiac events by 19%.
- The MAYO article also commented: Omega 3 fatty acid supplementation lowered cardiovascular risk both in GISSI-P and JELIS showed that despite aggressive therapy with standard pharmacotherapy(e.g. statins, aspirins, beta blockers, and ace inhibitors). Combination therapy with omega 3 fatty acids and a statin is a safe and effective way to improve lipid levels and cardiovascular prognosis beyond benefits provided by statin therapy alone
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