Proteins and Peptides are some of the most commonly used reagents in modern life sciences. From short-chain peptide receptor agonists to biotinylated-antibodies, peptide-based reagents play pivotal roles in every stage of research. The ubiquity of peptides has created a vibrant market for them and protein reagents with many suppliers at different levels. However, not all peptide suppliers are the same, and neither are their products. Therefore, the first step to ordering research peptides online is to identify whether a supplier’s products are of the exacting standards needed to conduct effective research.

Bad reagents can ruin an experiment and potentially sink entire projects. More insidiously, research conducted with poorly tested components can get published and contribute to the growing reproducibility crisis in science¹. In recent decades, irreproducibility has been brought to the forefront in science, with journals like Nature publishing extensively on the topic^2,3. In 2015, one study estimated that up to 50% of preclinical research is irreplicable. This has cost approximately $28,000,000,000 in US dollars⁴.

One key point made by some authors is that differences in reagents, especially protein products like antibodies, have made achieving reproducible results difficult. Therefore, identifying which protein and Peptide Products are validated is crucial. There are databases and websites in which antibodies from different manufacturers are listed and compared for efficacy, with links to studies that use them⁵. However, there is no such catalog or comparable resource for small peptide products⁶. This doesn’t mean that there is no way to be sure your peptide products are of the purity and quality you expect.

Peptide products should undergo quality control analysis through multiple methods. These techniques include high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance analysis (NMR)^7-9. A reputable supplier will have quality control reports available on their product pages for some or all of these. Therefore, when shopping for research peptides online, it is pivotal to find quality control reports.

Another factor to consider when shopping for research peptides online is customer service and accountability. Research is not a simple endeavor. Along the course of a project, it is a given that some experiments will not work out. In some cases, this is caused by the reagent. Even high-grade products will not work when used outside of their working conditions. By having direct contact with a peptide supplier, a researcher can troubleshoot issues that arise with their research peptide products. Additionally, a good return policy helps avoid losses if the product is not up to standards or does not match the application.

Finally, and perhaps most obviously, pricing is critical. Research funds aren’t unlimited, and materials are only one of many costs that an investigator or lab manager must account for. Many suppliers offer scaling pricing options and periodic special offers. Additionally, some retailers have rewards programs that encourage repeat business.

When searching for research peptides online, Blue Sky Peptides offers affordable peptides that come with quality control reports. We have in-depth customer support and a generous return policy. In addition, our site has regular sales, BOGO offers, discount codes, and our BSP Rewards Program. Visit our website or contact us today to see if our research peptides will meet your research needs.

References:

1. Williams M. Reagent Validation to Facilitate Experimental Reproducibility. Curr Protoc Pharmacol. 2018;81(1):e40.
2. Baker M. 1,500 scientists lift the lid on reproducibility. Nature. 2016;533(7604):452-454.
3. Begley CG, Ioannidis JP. Reproducibility in science: improving the standard for basic and preclinical research. Circ Res. 2015;116(1):116-126.
4. Freedman LP, Cockburn IM, Simcoe TS. The Economics of Reproducibility in Preclinical Research. PLoS Biol. 2015;13(6):e1002165.
5. Antibodypedia. https://www.antibodypedia.com/. Accessed August 28, 2021.
6. Vergote V, Burvenich C, Van de Wiele C, De Spiegeleer B. Quality specifications for peptide drugs: a regulatory-pharmaceutical approach. J Pept Sci. 2009;15(11):697-710.
7. Choules MP, Bisson J, Gao W, et al. Quality Control of Therapeutic Peptides by (1)H NMR HiFSA Sequencing. J Org Chem. 2019;84(6):3055-3073.
8. Stalmans S, Gevaert B, Verbeke F, et al. Quality control of cationic cell-penetrating peptides. J Pharm Biomed Anal. 2016;117:289-297.
9. Zeng K, Geerlof-Vidavisky I, Gucinski A, Jiang X, Boyne MT, 2nd. Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control. AAPS J. 2015;17(3):643-651.

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