In recent years, the demand for NMN (nicotinamide mononucleotide) Supplements has increased in the wellness and health industry. NMN is a naturally occurring substance in the body, and it is well-known for its ability to stimulate the creation of cellular energy.
In this article, we will provide you with a thorough grasp of Nmn Supplements and how they improve our overall health. We will review everything you need to know about NMN supplements, including their benefits, how much they cost, their side effects, and more!
Table of Contents
What is NMN?
Nicotinamide mononucleotide (NMN) is a molecule that occurs naturally in the nucleotide family. It is essential in many biological functions, including energy metabolism and cellular health. NMN is a precursor to another molecule known as nicotinamide adenine dinucleotide (NAD+), which is involved in various enzymatic activities throughout the body. [1][2]
NAD+ is required for the creation of cellular energy, the repair of DNA, and the control of different cellular activities. However, because NAD+ levels tend to fall as we age, there has been a lot of interest in NMN as a possible anti-aging and health-promoting supplement. [2]
What are the benefits of NMN supplements?
The primary purpose of NMN supplements is to support and perhaps improve many elements of health and well-being. As we mentioned earlier, NMN occurs naturally in our bodies, and it is required to form nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in various biological activities. [1][2]
NMN is known for its various amazing benefits, here are all of the well-known uses of NMN if it’s taken in supplement form:
Greatly aids in generating cellular energy
One of the most common applications for NMN supplements is to boost NAD+ levels, which in turn helps with cellular energy generation. [2]
NAD+ contributes to critical metabolic processes such as oxidative phosphorylation and glycolysis, where it assists in the conversion of nutrients into usable energy in the form of adenosine triphosphate (ATP). NMN supplements may improve overall energy expenditure and mitochondrial activity by restoring NAD+ levels. [2]
Helps fight signs of aging and increase overall life expectancy
There has been a significant rise in interest in NMN supplements because of their possible contributions to slowing down aging and extending one’s lifespan. NAD+ levels normally fall as we age, and this decline has been linked to various age-related health concerns. [1][3]
NMN supplements may help mitigate these effects by increasing NAD+ levels, supporting healthy cell functions, repairing DNA, and controlling gene expression. [2][3]
While additional study is still needed to confirm these claims, preliminary studies in animal models have shown encouraging effects regarding lifespan extension and enhanced health span. [4]
Promotes metabolic wellness
NMN supplements might have positive impacts on the metabolism. NAD+ is involved in metabolic activities such as lipid and glucose metabolism. NMN supplements can potentially increase sensitivity to insulin, glucose consumption, and the breakdown of lipids by increasing NAD+ levels. [2][5]
This might be especially useful in treating illnesses such as obesity, type 2 diabetes, and issues with metabolism. [6][7]
Helps improve cardiovascular health
There have been studies on the possible cardiovascular advantages of NMN supplementation. NAD+ contributes to the health and function of blood arteries and the heart. NMN supplements may improve endothelial function, reduce stress caused by oxidation, and increase blood vessel strength by increasing NAD+ levels. [5][6]
Helps enhance cognitive function
Numerous research evidence shows that NMN supplements may improve cognitive performance by boosting NAD+ formation. NAD+ contributes to brain wellness, synaptic flexibility, and mitochondrial activity in the brain. [6][7][8]
Do NMN supplements have side effects?
As of now, NMN supplements have had a positive safety profile. Studies on both human and animal models have shown no substantial negative effects. Nonetheless, long-term safety and possible drug interactions have not been thoroughly investigated. [4][6]
How much do NMN supplements cost?
The price of NMN supplements varies according to the brand, the dosage, and the amount you will purchase. As of writing this article, a month’s supply of NMN pills normally costs between $30 and $100.
What is the recommended dosage for NMN supplements?
Due to the small number of trials that have been completed thus far, the ideal dose for NMN supplements has yet to be determined. However, the majority of research investigations have safely employed daily dosages that range from 250 mg to 1,000 mg. [9][10]
Are NMN supplements safe?
Based on existing research, NMN supplements appear to be safe for ingestion. Although, long-term safety research is currently still insufficient, and possible drug interactions have not been adequately examined. [11][12]
Bottomline
NMN supplements have a lot of potential as a tool for promoting healthy aging and general well-being. While the preliminary study reveals various advantages, further research is still required to completely understand the long-term effects, ideal doses, and potential supplementary interactions.
Before introducing NMN supplements to your regimen, like with any dietary supplement, you should contact a healthcare expert. By doing so, you can make well-informed choices to improve your health and extend your life expectancy.
FAQs
Disclaimer: This article is only a guide. It does not substitute the advice given by your healthcare professional. Before making any health-related decision, consult your healthcare professional.
Editorial References And Fact-Checking
- Nadeeshani, H., Li, J., Ying, T., Zhang, B., & Lu, J. (2021). Nicotinamide mononucleotide (NMN) as an anti-aging health product – Promises and safety concerns. Journal of advanced research, 37, 267–278. https://doi.org/10.1016/j.jare.2021.08.003
- Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P. E., Zhou, X., Li, C., Shen, G., & Zou, B. (2020). NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential. Signal transduction and targeted therapy, 5(1), 227. https://doi.org/10.1038/s41392-020-00311-7
- Baumgart M, Snyder S. The Telomere Effect: A Revolutionary Approach to Living Younger, Healthier, Longer. Grand Central Publishing; 2018.
- Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., Csipo, T., Farkas, E., Wren, J. D., Garman, L., Csiszar, A., & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 42(2), 527–546. https://doi.org/10.1007/s11357-020-00165-5
- Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013 Dec 19;155(7):1624-38. doi: 10.1016/j.cell.2013.11.037. PMID: 24360282; PMCID: PMC4076149.
- Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 Jun;24:101192. doi: 10.1016/j.redox.2019.101192. Epub 2019 Apr 10. PMID: 31015147; PMCID: PMC6477631.
- Hong W, Mo F, Zhang Z, Huang M, Wei X. Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism. Front Cell Dev Biol. 2020 Apr 28;8:246. doi: 10.3389/fcell.2020.00246. PMID: 32411700; PMCID: PMC7198709.
- Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA. Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife. 2018 Jun 12;7:e33246. doi: 10.7554/eLife.33246. PMID: 29893687; PMCID: PMC6013257.
- Yoshino M, Yoshino J, Kayser BD, Patti GJ, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021 Jun 11;372(6547):1224-1229. doi: 10.1126/science.abe9985. Epub 2021 Apr 22. PMID: 33888596; PMCID: PMC8550608.
- Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ. Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise. Sci Rep. 2017 Nov 8;7(1):15063. doi: 10.1038/s41598-017-14866-z. PMID: 29118320; PMCID: PMC5678092.
- Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188.
- Yi L, Maier AB, Tao R, Lin Z, Vaidya A, Pendse S, Thasma S, Andhalkar N, Avhad G, Kumbhar V. The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial. Geroscience. 2023 Feb;45(1):29-43. doi: 10.1007/s11357-022-00705-1. Epub 2022 Dec 8. PMID: 36482258; PMCID: PMC9735188.
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