With medical advancements, IVF has emerged as a boon for infertile couples. In-vitro Fertilisation has registered massive success rates around the globe. IVF success rates are influenced by a plethora of factors. A woman’s age is one of the predominant factors in deciding the Ivf Treatment success rates. So, quite naturally every couple wants to dive into the depths of IVF success rates by age. Imprimis IVF, the best IVF center in Srinagar, is here to help you with your questions.
IVF success rates by age and number of embryos
Medical experts have concluded that the best age for a woman to welcome a baby is between 24 to 30. During this age, the woman is both physically and mentally armed to start a family of her own. However, there have been cases where a woman is unable to conceive at an early age and has to turn to IVF.
The IVF success rate lies between 30-40%.
IVF success rates revolve around the age of 35. Doctors divide the IVF success rate into two age groups.
- IVF success rates under 35
- IVF success rates after 35
Two important parameters describe IVF success rates. One is the “clinical pregnancy rate” and the other is the “live pregnancy rate“.
Clinical pregnancy rate means how many women are successful in conceiving a baby per IVF cycle. Whereas live birth rate means how many women give birth to a healthy baby with IVF.
Now, let’s understand how these two parameters determine the IVF success rate with the help of two cases.
IVF success rates under 35
Suppose a 31 years old woman is undergoing IVF treatment at Imprimis IVF, Srinagar. We can describe the success rate for 31-year-old women with the aforementioned parameters. The chances of conceiving a baby or clinical pregnancy rates are around 40%. But the live birth rate for this woman with IVF treatment is between 33-36%.
IVF success rates over 35
As a woman crosses the border age of 35, a steep decline is witnessed in clinical pregnancy rates as well as live birth rates. The clinical pregnancy rate declines from 40% to 25-30%. Whereas the live birth rate over 35 stands at 20%.
IVF success rates over 40
After hitting 40, there is a natural and consistent decrease in both the quantity and quality of your eggs. As a result, the success rate of IVF at 40 decreases considerably. The clinical pregnancy as well as the live birth rates plummet further. The chances of pregnancy between 40-42 with a woman’s own eggs are about 16% and the live birth rate is around 10%.
For women between 43-44, the chances are further reduced to 7%.
After clocking 45, the IVF success rate is just 2-3%.
Women over 40 can consider taking the help of donor egg IVF treatment after consulting with their reproductive specialist.
IVF Success Rate By Number Of Embryos.
The number of embryos along with their quality can increase or decrease the distance between you and your baby. The uterus must produce a large number of good-quality eggs that can be implanted in the uterus during IVF and helps in conceiving.
But this doesn’t mean implanting more embryos will increase your stakes of achieving pregnancy. Let’s understand how the number of embryos influences IVF success rates.
Single vs. Multiple embryos-
Single Embryo Transfer is preferred over multiple/double embryo transfer in IVF treatment. The most pronounced reason is that multiple embryo transfer results in more complications and negative outcomes. Multiple embryo transfer increases the risk of twin pregnancy which further impacts the health of the baby. The risk is higher when the woman is over 35. The efficacy rates of single embryo transfer are observed to stand at around 42%. 2 embryo success transfer rates are around 45%.
Frozen embryo transfer success rates-
Frozen embryo transfer technology is on the rise these days in India. In some cases, excellent results are summoned with frozen embryo transfer instead of fresh egg transfer.
The embryo transfer success rates lie between 50-60%.
Why IVF Success rate Decreases with Age
1. Diminishing Ovarian Reserve (Reduced Egg Quality and Quantity)-: The ovarian reserve diminishes as a woman ages. Reduction in egg quality and quantity is natural and irreversible.
The IVF treatment cost in Srinagar also increases accordingly.
2. Poor Embryo Quality-: There’s a difference between the appearance (morphology) of an embryo and its quality. Defected/abnormal embryos fail to implant into the uterus after their transfer.
Other Factors Impacting IVF Success Rates-
1. No Ovarian Response -: There are 4 stages of IVF, during the first stage a woman is on medications to increase the production of eggs. In women with low levels of AMH, the ovaries will not respond to these medications and IVF treatment will not yield success.
2. Sperm Quality-:Fertilization involves the fusion of eggs with sperm. Poor quality sperm is bound to impact IVF success rates.
3. Lifestyle-: Consumption of alcohol, smoking, and being underweight or overweight have a direct impact on IVF success rates.
How to make IVF successful the first time?
No IVF treatment center can guarantee 100% success rates. However, there are certain precautionary steps that you can take to reduce your number of IVF cycles.
- Choosing the right IVF clinic-: IVF is a complex Assisted Reproductive Technology. Choosing the right clinic that is armed with excellent medical expertise, and state-of-the-art lab fertility technology like Imprimis IVF which delivers the best IVF treatment in Srinagar can increase your chances of having your little human by a good percentage. The right IVF clinic can be a game-changer!
- Keep your dosage and medication timing in check-: Don’t risk skipping your IVF medications. Take your daily dose of IVF medications at the proper time without fail.
- A healthy lifestyle with a balanced diet-: After the embryo implantation, the woman should consume a diet rich in fruits and green leafy vegetables. Some doctors recommend consuming small and frequent balanced diets. Adequate water intake is a must. Refrain from consuming bakery products that contain excess sugar. Abstain from smoking and drinking to increase the efficacy of the IVF treatment.
- No strict bed rest-: It might come as a shock, but strict bed rest can prove to be an enemy. As a woman is constantly dreaded with thoughts about conceiving, what if it fails? If strict bed rest is followed then these negative thoughts thrive. This in turn increases the secretion of stress hormones which contract the uterus.
- Positivity and belief are important-: Staying positive and believing that your IVF journey will push you toward your baby is vital.
Donor Egg IVF Success Rates-
As we’ve already learned that the number and quality of eggs decrease sharply once a woman crosses 35. This means the chances of conceiving with one’s own eggs also decrease. But that doesn’t mark the end of the road to pregnancy. Donor egg IVF treatment has summoned a promising live birth rate of around 19% in elderly women.
IVF success rate by age with PGS.
One of the pronounced reasons why IVF treatment fails is genetic abnormalities in the embryo. Either this abnormal embryo will not implant in the uterus lining or will result in miscarriage. The genetic abnormalities in the embryo increase with age. This significantly hampers the IVF success rates amongst women over 35.
PGS or PGD or PGT stands for Preimplantation Genetic Testing. This medical test involves genetic testing of the blastocyst (day 5) embryos before implantation. PGS removes the hurdle of chromosome abnormalities and increases success rates. However, PGS is prescribed in special cases only:
- Women over 38 years of age
- Multiple IVF failures
- Recurrent pregnancy losses
- History of previous abnormal pregnancy
- Severe male infertility issues
- Background of serious genetic conditions
Shedding light on the success rate of IVF treatment with PGS, positive results are summoned amongst elderly women.
IVF success rate by age and AMH
AMH which stands for Anti-Mullerian hormone is a hormone secreted by primordial follicles in your ovaries. Why do AMH levels play a vital role in determining IVF success rates? AMH is a predictive biomarker that predicts/indicates the ovarian reserve of a woman.
Normal AMH level for healthy pregnancy ranges between 1.0-4.0ng/ml. The anti-Mullerian hormone is an age-dependent parameter. Studies have shown that the ovarian reserve or the AMH level is reduced by 10% every year. As a woman ages, the number of primordial follicles decreases. So, the AMH level decreases. AMH levels for different ages decrease in the following order:
- At 25 – 3ng/ml
- At 30 – 2.5ng/ml
- At 35 – 1.5ng/ml
- At 40– 1ng/ml
- At 45 – 0.5ng/ml
The AMH level varies and provides crucial data about ovarian reserve to predict success rates.
Conclusion
Before choosing IVF, doing proper research about IVF success rates by age proves to be helpful. But nothing can beat talking to a reproductive specialist to chalk out a plan for your age. For example, if you are at 25, discuss what are the IVF success rates at 25, medical requirements, and everything that concerns you. Make sure you pay a visit at the right clinic, take your medications religiously and stay super positive!
References-:
https://www.verywellfamily.com/what-are-the-chances-for-ivf-success-1960213
https://advancedfertility.com/2020/09/16/fertility-after-age-40-ivf/
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