CHICAGO — Ringing in the White Sox home opener Monday, it was the Giants who threw a party. Call it a Disco-dinger bash.

Rebounding from a season-opening series loss in New York, the Giants launched seven home runs — four in one inning — while Anthony DeSclafani turned in six sharp frames in a 12-3 win. It even featured a special guest, DeSclafani’s fiery alter ego (Tony Disco?) who jawed and lunged at a Chicago player, just one of many retired by the San Francisco right-hander in his first start since last June.

DeSclafani’s counterpart, White Sox starter Michael Kopech, proved to be just the medicine San Francisco’s bats needed after being blanked twice in their first three games of the season, 5-0 on Opening Day and again, 6-0, on Sunday.

“That Sunday loss really left a bad taste in our mouth,” said third baseman David Villar, who contributed two of the homers, including a ninth-inning grand slam that sealed the win. “We wanted to come out here and get things rolling.”

Joc Pederson got the party started in the second inning with a no-doubter to right-center — his second of the season — and he would have had another if not for Luis Robert’s leaping catch at the center field wall. No worry, though, Pederson was merely setting the stage for the power parade to come.

The Giants would go back-to-back not once, but twice in the fifth inning, with consecutive blasts from Michael Conforto and Thairo Estrada, and then Mike Yastrzemski and Villar. All the while, the White Sox left in their struggling starter, who was visibly growing more frustrated and flustered with each long ball.

Before yielding to Sean Manaea, as the Giants tag-teamed two of their seven starting pitchers, DeSclafani couldn’t relate to Kopech’s trouble getting outs, but he did show some emotion early that almost emptied the benches onto the field. After Chicago second baseman Andrew Vaughn, a Santa Rosa native, grounded out softly on a 3-0 pitch in the second inning, the Giants starter began barking at him and had to be restrained by first baseman LaMonte Wade Jr., but only after Vaughn’s reaction to the pitch.

“I think he was just upset that I threw a 3-0 slider,” DeSclafani said. “And that he hit it 10 feet. … He didn’t say a nice word to me, so I just said something back.”

The well-executed slider was emblematic of the rest of DeSclafani’s day, an encouraging sign for the Giants, who hope to get him back to his 2021 form. DeSclafani allowed little hard contact and located all three of his primary pitches.

“It couldn’t have gone better for Tony,” Kapler said.

“I felt like I was just throwing strikes with everything,” DeSclafani said. “The two-seam (and) the slider, I guess you could call them the keys to the game.”

Making his first appearance with the Giants, Manaea walked the first two batters he faced and surrendered all of Chicago’s three runs. But he also registered the fastest pitch of his career — 97.2 mph, the hottest heater of the game — and Kapler commended his willingness to move into a relief role, at least temporarily.

Between DeSclafani and Manaea, the Giants got eight innings of three-run ball, leaving Tyler Rogers to finish the game with a clean ninth inning.

“It’s a huge deal for us to know that we had those two guys to take the bulk of the game,” Kapler said. “(Manaea) is going to start a lot of games for us as well, but it was a sacrifice when we made this plan in spring training and we saw the fruits of that sacrifice today.”

Kopech who became the first starter since the Reds’ Bill Gullickson on June 25, 1987 at Candlestick Park to serve up five home runs to the Giants (h/t Andrew Baggarly). With the blasts from Conforto, Estrada, Yastrzemski and Villar, the Giants slugged four homers in one inning for the first time since Sept. 18, 2011, at Coors Field. Since moving to San Francisco, the club had never had players go back-to-back twice in an inning.

Conforto’s homer — his first with the Giants and his first at all since Oct. 2, 2021, before he suffered a shoulder injury that required surgery and cost him all of last season — came with two strikes (and got out in a hurry, leaving the bat at 109 mph), while Villar and Yastrzemski’s back-to-back blasts came with two outs.

“I gotta give credit to them,” Villar said. “They provided the rally. I just jumped in on the fun.”

The real celebration came postgame in the clubhouse, as Giants players doused rookie Bryce Johnson, who snuck a line drive over the right field fence in the ninth inning for his first big-league home run. It landed in a good spot, in the visitor’s bullpen, making the souvenir an easy retrieval.

“Oh,” Johnson said, smiling, “I got dunked in there. Ketchup, mustard, everything you could possibly put on a pancake, it was on me in there.”

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San Francisco finished one dinger shy of matching a single-game franchise record (eight vs. the Milwaukee Braves on April 30, 1961) but will have to settle for the seventh seven-homer game in franchise history, last done July 2, 2002, at Coors Field.

Between their seven home runs and DeSclafani’s six shutout innings, was there one part of Monday’s game that was particularly encouraging for the Giants’ manager?

“Do I have to choose one?” Kapler said, smiling.

Notable

— Estrada left the game after fouling a pitch off his leg, a move Kapler said was merely precautionary. He finished his plate appearance, drawing a walk, but was replaced by pinch-runner J.D. Davis.

— Injured outfielders Mitch Haniger (oblique) and Austin Slater (hamstring) will meet the team in San Francisco, though it’s unlikely either is activated in time for Friday’s home opener. Slater is “beginning to feel really good,” manager Gabe Kapler said, while Haniger is “just a little bit behind him.”

— The Giants’ top pitching prospect, 21-year-old left-hander Kyle Harrison, will make his season debut on Tuesday for Triple-A Sacramento. It will be the River Cats’ home opener. While newly signed catcher Gary Sánchez may not be behind the plate for Harrison’s start, he is expected to join Sacramento “in the next couple days,” Kapler said.