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How Long Does A High Last? Effects Of Substance Use & Abuse

How Long Does A High Last? Effects Of Substance Use & Abuse

It is never safe to take "just one" dosage of a previously addictive drug, and it is seldom safe to take any potentially addictive drug at all. Continue to learn more about how long does a high last and for recovery resources.

By We Level Up | Editor Yamilla Francese | Clinically Reviewed By Lauren Barry, LMFT, MCAP, QS, Director of Quality Assurance | Editorial Policy | Research Policy | Last Updated: February 10, 2023

How Long Does A High Last For?

The length of time it takes for a person to feel high is determined by both physical and psychological factors, such as weight, gender, and the expected reaction. Scientific study has shown that people who expect a strong high will experience intoxication symptoms long before the Substance reaches their brains, and even after consuming something that contains no actual drugs.

Individuals vary in the development and progression of substance use disorders. Not only are some people more likely to use and misuse substances than others and to progress from initial use to Addiction differently, but individuals also differ in their vulnerability to relapse and in how they respond to substance use disorder treatments. For example, some people with substance use disorders are particularly vulnerable to stress-induced relapse, but others may be more likely to resume substance use after being exposed to drug-related cues.

The problem with taking drugs to make yourself feel better “just this once” is that “once” is rarely enough. The transient exhilaration of a “high” becomes a seductive or deceptive feeling pulling the user back to relive that sensation long before physical addiction takes hold. And, more often than not, the duration and enjoyment of the high are inversely proportionate to the extent of drug dependence.

How Long Does A High Usually Last? The Neurobiology Of Substance Use, Misuse, And Addiction

How long does a high last when you use or consume drugs of abuse? The duration of the high is generally determined by the mode of administration:

  • Inhalation or smoking: Several seconds to 15 minutes. Drugs that enter the body through the lungs go through the bloodstream to the brain. Because foreign chemicals in the lungs take up space typically occupied by oxygen, low oxygen levels can also contribute to feeling lightheaded or “high.”
  • Injection: Between 30 seconds and 20 minutes. Again, injecting the drug straight into circulation ensures that it reaches the brain as soon as possible.
  • Oral administration (pills, eating, or drinking): Around 30-90 minutes, maybe longer for slow-release tablets taken whole. When a drug enters the body through the digestive system, it takes a long time to reach circulation, delaying the start of full effects.

As use becomes an ingrained behavior, impulsivity shifts to compulsivity, and the primary drivers of repeated substance use shift from positive reinforcement (feeling pleasure) to negative reinforcement (feeling relief), as the person seeks to stop the negative feelings and physical illness that accompany withdrawal. Eventually, the person begins taking the substance not to get “high,” but rather to escape the “low” feelings to which, ironically, chronic drug use has contributed. Compulsive substance seeking is a key characteristic of addiction, as is the loss of control over use. Compulsivity helps to explain why many people with addiction experience relapse after attempting to abstain from or reduce use.

The following sections provide more detail about each of the three stages—binge/intoxication, withdrawal/negative effects, and preoccupation/anticipation—and the neurobiological processes underlying them.

Binge/Intoxication Stage: Basal Ganglia

The “reward circuitry” of the basal ganglia (a group of structures near the center of your brain that form important connections), along with dopamine and naturally occurring opioids, play a key role in the rewarding effects of alcohol and other substances and the ability of stimuli, or cues, associated with that substance use to trigger craving, substance seeking, and use.

As alcohol or substance use progresses, repeated activation of the “habit circuitry” of the basal ganglia (i.e., the dorsal striatum) contributes to the compulsive substance seeking and taking that are associated with addiction.

The involvement of these reward and habit neurocircuits helps explain the intense desire for the substance (craving) and the compulsive substance seeking that occurs when actively or previously addicted individuals are exposed to alcohol and/or drug cues in their surroundings.

All addictive substances produce feelings of pleasure. These “rewarding effects” positively reinforce their use and increase the likelihood of repeated use. The rewarding effects of substances involve activity in the nucleus accumbens, including activation of the brain’s dopamine and opioid signaling system. Many studies have shown that neurons that release dopamine are activated, either directly or indirectly, by all addictive substances, particularly by stimulants such as cocaine, amphetamines, and nicotine.

Furthermore, the brain’s opioid system, which includes naturally occurring opioid molecules (i.e., endorphins, enkephalins, and dynorphins) and three types of opioid receptors (i.e., mu, delta, and kappa), plays a key role in mediating the rewarding effects of other addictive substances, including opioids and alcohol. Activation of the opioid system by these substances stimulates the nucleus accumbens directly or indirectly through the dopamine system.

Withdrawal/Negative Affect Stage: Extended Amygdala

The withdrawal/negative affect stage of addiction follows the binge/intoxication stage, and, in turn, sets up future rounds of binge/intoxication. During this stage, a person who has been using alcohol or drugs experiences withdrawal symptoms, which include negative emotions and, sometimes, symptoms of physical illness, when they stop taking the substance. Symptoms of withdrawal may occur with all addictive substances, including marijuana, though they vary in intensity and duration depending on both the type of substance and the severity of use. The negative feelings associated with withdrawal are thought to come from two sources: diminished activation in the reward circuitry of the basal ganglia, and activation of the brain’s stress systems in the extended amygdala

When used over the long term, all substances of abuse cause dysfunction in the brain’s dopamine reward system. For example, brain imaging studies in humans with addiction have consistently shown long-lasting decreases in a particular type of dopamine receptor, the D2 receptor, compared with non-addicted individuals. Decreases in the activity of the dopamine system have been observed during withdrawal from stimulants, opioids, nicotine, and alcohol.

This stage of addiction involves a decrease in the function of the brain reward systems and activation of stress neurotransmitters, such as CRF and dynorphin, in the extended amygdala. Together, these phenomena provide a powerful neurochemical basis for the negative emotional state associated with withdrawal. The drive to alleviate these negative feelings negatively reinforces alcohol or drug use and drives compulsive substance taking.

Preoccupation/Anticipation Stage: Prefrontal Cortex

The preoccupation/anticipation stage of the addiction cycle is the stage in which a person may begin to seek substances again after a period of abstinence. In people with severe substance use disorders, that period of abstinence may be quite short (hours). In this stage, an addicted person becomes preoccupied with using substances again. This is commonly called “craving.” Craving has been difficult to measure in human studies and often does not directly link with relapse.

This stage of addiction involves the brain’s prefrontal cortex the region that controls executive function: the ability to organize thoughts and activities, prioritize tasks, manage time, make decisions, and regulate one’s own actions, emotions, and impulses. 

How long does a high last? It could be a few minutes or a few hours, but it is a rough estimate. Generally, it depends: Did you smoke it, vape it, eat it, or dab it?

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Learn More:

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  • Opioid Overdose Symptoms
  • Drug Overdose Record
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  • Inpatient Drug Detox

What Is Addiction?

Addiction can be described as a repeating cycle with three stages. Each stage is particularly associated with one of the brain regions described above—basal ganglia, extended amygdala, and prefrontal cortex. This three-stage model draws on decades of human and animal research and provides a useful way to understand the symptoms of addiction, how it can be prevented and treated, and how people can recover from it. The three stages of addiction are:

  • Binge/Intoxication is the stage at which an individual consumes an intoxicating substance and experiences its rewarding or pleasurable effects;
  • Withdrawal/Negative Affect, the stage at which an individual experiences a negative emotional state in the absence of the substance; and
  • Preoccupation/Anticipation is the stage at which one seeks substances again after a period of abstinence.

Drug Addiction Facts

Addiction is defined as a chronic, relapsing disorder characterized by compulsive drug seeking and use despite adverse consequences. It is considered a brain disorder, because it involves functional changes to brain circuits involved in reward, stress, and self-control. Those changes may last a long time after a person has stopped taking drugs.


What is drug use?

Drug use, or misuse, includes:

  • Using illegal substances, such as
    • Anabolic steroids
    • Club drugs
    • Cocaine
    • Heroin
    • Inhalants
    • Marijuana
    • Methamphetamines
  • Misusing prescription medicines, including opioids. This means taking the medicines in a different way than the health care provider prescribed. This includes
    • Taking a medicine that was prescribed for someone else
    • Taking a larger dose than you are supposed to
    • Using the medicine in a different way than you are supposed to. For example, instead of swallowing your tablets, you might crush and then snort or inject them.
    • Using the medicine for another purpose, such as getting high
  • Misusing over-the-counter medicines, including using them for another purpose and using them in a different way than you are supposed to

Drug use is dangerous. It can harm your brain and body, sometimes permanently. It can hurt the people around you, including friends, families, kids, and unborn babies. Drug use can also lead to addiction.

What are the treatments for drug addiction?

Treatments for drug addiction include counseling, medicines, or both. Research shows that combining medicines with counseling gives most people the best chance of success.

The counseling may be individual, family, or group therapy. It can help you:

  • Understand why you got addicted
  • See how drugs changed your behavior
  • Learn how to deal with your problems so you won’t go back to using drugs
  • Learn to avoid places, people, and situations where you might be tempted to use drugs

Medicines can help with the symptoms of withdrawal. For addiction to certain drugs, some medicines can help you re-establish normal brain function and decrease your cravings.

It is a dual diagnosis if you have a mental disorder and addiction. It is crucial to treat both problems. This will increase your chance of success.

You may need hospital-based or residential treatment if you have a severe addiction. Residential treatment programs combine housing and treatment services.

Drug use and addiction are preventable. Prevention programs involving families, schools, communities, and the media may prevent or reduce drug use and addiction. These programs include education and outreach to help people understand the risks of drug use.

How long does a high last? Depending on the amount of addictive substance consumed and your tolerance for it, a drug high can last a few hours to a full day.

Top 5 How Long Does A High Last? FAQs

  1. How long does a lean high last?

     Lean, known as Purple Drank or Sizzurp, is a mix containing Codeine cough syrup and soda. Lean addiction and abuse can rapidly develop. Lean gets its name from the user’s loss of balance, which is similar to the behavior of heroin and opioid users. The effects of drinking Lean will appear about an hour after taking the first drink and may last for up to six hours afterward.

  2. How long does a pen high last?

    How long does a high from weed last? A dab pen high is much stronger because dab weed is concentrated cannabis that can have four times the amount of THC compared to normal weed. Similar to smoking, the effects of dabbing usually last 1 to 3 hours. If using a high-THC concentrate, you could feel the effects for an entire day.

  3. How long does a high last from weed? How long does a bong high last?

    How long does a high last when you smoke marijuana? Smoking marijuana via a joint, blunt, pipe, or bong usually leads to effects within 2 to 10 minutes, and the high lasts for 1 to 3 hours.

  4. How long does a DXM high last?

    DXM is a common cough suppressant. The cough-suppressing effects of DXM persist for 5 to 6 hours after ingestion. When consumed at inappropriately high doses (over 1500 mg/day), DXM can induce a state of psychosis characterized by Phencyclidine (PCP)-like psychological symptoms, including delusions, hallucinations, and paranoia.

  5. How long does a PCP high last?

    PCP, or phencyclidine, is a dangerous drug that was originally developed as an anesthetic. PCP is an illegal hallucinogenic drug. It can trigger a sense of detachment but also aggression and other behavior changes.

Drug Addiction Statistics

The positively reinforcing effects of substances tend to diminish with repeated use. This is called tolerance and may lead to the use of the substance in greater amounts and/or more frequently in an attempt to experience the initial level of reinforcement. Eventually, in the absence of the substance, a person may experience negative emotions such as stress, anxiety, or depression, or feel physically ill. This is called withdrawal, which often leads the person to use the substance again to relieve the withdrawal symptoms.

If you are thinking of seeking drug addiction treatment for yourself or a loved one, you are not alone. The number of people suffering from substance use disorders in the US is astounding. Here are some reports from the Substance Abuse and Mental Health Services Administration. [2]


59.3 Million

More than 59.3 million people 12 or older used illicit drugs in the past year, including 49.6 million who used marijuana. 

Source: SAMHSA

2 out of 3

Two out of three drug overdose deaths in 2018 involved an opioid.

Source: SAMHSA

10.1 Million

In 2019, an estimated 10.1 million people aged 12 or older misused opioids in the past year. Specifically, 9.7 million people misused prescription pain relievers, and 745,000 people used heroin.

Source: SAMHSA


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How Long Does A Weed High Last?

The quickest way to get high with weed is to smoke or vape. How long does a high last when you use weeds? The effects will be most noticeable after 10 minutes. The high typically lasts one to three hours, although the effects might last up to eight hours. It used to be considerably more difficult to predict how long does a weed high last for users.

Experienced smokers might try to determine the intensity of a bud by looking at it and smelling it. However, relying just on sight and aroma is not an exact science. However, things have gotten a lot easier after stores began advertising the actual THC level of their products. If you are new to cannabis, it is best to start carefully.

How long does a marijuana high last? Within a few minutes after inhaling marijuana smoke, a person’s heart rate speeds up, the breathing passages relax and become enlarged, and blood vessels in the eyes expand, making the eyes look bloodshot. The heart rate—normally 70 to 80 beats per minute—may increase by 20 to 50 beats per minute or may even double in some cases. Taking other drugs with marijuana can amplify this effect.

Searching for “How long does a pot high last” or “How long does a cannabis high last?” Knowing how long weed highs last will help you organize your day. You might consider timing your high for optimal enjoyment. Or maybe you have something later in the day that you don’t want to be too high for. Furthermore, certain states may have adopted laws legalizing the recreational use of cannabis, but on the federal level, cannabis remains illegal.

The federal government classifies cannabis, along with heroin and cocaine, as a Schedule I drug with a high potential for abuse and little to no medical benefit. Cannabinoids such as delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of marijuana, target the brain’s internal or endogenous cannabinoid system. This system also contributes to reward by affecting the function of dopamine neurons and the release of dopamine in the nucleus accumbens.

Like other drugs, marijuana (also called cannabis) leads to increased dopamine in the basal ganglia, producing a pleasurable high. It also interacts with a wide variety of other systems and circuits in the brain that contain receptors for the body’s natural cannabinoid neurotransmitters. Effects can be different from user to user, but often include distortions in motor coordination and time perception. Cannabis addiction follows a pattern similar to opioids.

How long does a high last? This pattern involves a significant binge/intoxication stage characterized by episodes of using the substance to the point of intoxication. Over time, individuals begin to use the substance throughout the day and show chronic intoxication during waking hours. Withdrawal is characterized by negative emotions, irritability, and sleep disturbances. Although the craving associated with cannabis has been less studied than for other substances, it is most likely linked to both environmental and internal states, similar to those of other addictive substances.

Get The Facts – Marijuana Addiction

Top 5 How Long Does A THC High Last? FAQs

  1. How long does a CBD high last?

    CBD is a chemical found in marijuana. However, CBD doesn’t contain tetrahydrocannabinol (THC), the psychoactive ingredient found in marijuana that produces a high. The duration of CBD’s effects is determined by factors such as the dosage, your body, and the manner of administration. As a general rule, you should experience the benefits of CBD lasting two to six hours. The duration of CBD’s effects might be affected by your body type. Studies have shown that CBD may help reduce chronic pain by affecting endocannabinoid receptor activity, reducing inflammation, and interacting with neurotransmitters.

  2. How long does a joint high last?

    In general, the impact lasts around 10 minutes to half an hour after smoking cannabis, but if you smoke a lot, you may feel stoned for several hours. When you consume cannabis, the peak effects can continue for 2 to 4 hours, and the effects may linger for a few more hours before wearing off entirely.

  3. How long does a edible high last?

    With edible cannabis, the intoxicating effects or “high” do not kick in for about 30 minutes to two hours and peak at about four hours. How long does a high last? The effects can last up to 12 hours after use and residual effects can last up to 24 hours, so you could be affected into the next day.

  4. How long does a gummy high last?

    It takes anywhere from 30 minutes to 2 hours to begin to feel the effects of edible cannabis and up to 4 hours to feel the full effects. How long does a high last when you consume an edible? How long does a high last? The intoxicating effects can last up to 12 hours, with some residual effects lasting up to 24 hours, so you could be affected the next day.

  5. How long does a high from edibles last?

    Edibles take about 30 minutes to work and you could be high for up to 12 hours. Edibles are food items, usually sweet treats, made from or containing cannabis.

How Long Does A Fentanyl High Last?

Fentanyl is one of the most potent synthetic opioids available today. It’s 50 to 100 times stronger than morphine, a naturally occurring opioid derived from the seeds of the opium poppy plant. Fentanyl is a synthetic opioid medication that is used for severe pain management and is considerably more potent than heroin. Prescription fentanyl, as well as illicitly manufactured fentanyl and related synthetic opioids, are often mixed with heroin but are also increasingly used alone or sold on the street as counterfeit pills made to look like prescription opioids or sedatives.

How long does a high last when you use fentanyl? How long a fentanyl high lasts varies and depends on how much was taken, the person’s tolerance to the drug, its half-life, how it was used, and other factors. How long does a high last? When administered intravenously or through injection, fentanyl has a half-life of 2 to 4 hours. That implies fentanyl high might last anywhere from 11 to 22 hours after injection.

When you use fentanyl as a patch or lozenge, its half-life increases to 7 to 17 hours, which means adverse effects can last up to 36 hours. When fentanyl is broken down in the body, it leaves behind traces known as metabolites. Metabolites may remain in your system longer than Fentanyl side effects, implying that the substance may be found in drug tests for much longer than the high last.

Synthetic Drugs

Different classes of chemically synthesized (hence the term synthetic) drugs have been developed, each used in different ways and having different effects on the brain. Synthetic cathinone, more commonly known as “bath salts,” targets the release of dopamine in a similar manner as the stimulant drugs described above. To a lesser extent, they also activate the serotonin neurotransmitter system, which can affect perception. Synthetic cannabinoids, sometimes referred to as “K2”, “Spice”, or “herbal incense,” somewhat mimic the effects of marijuana but are often much more powerful. Drugs such as MDMA (ecstasy) and lysergic acid diethylamide (LSD) also act on the serotonin neurotransmitter system to produce changes in perception.

Not all people use substances, and even among those who use them, not all are equally likely to become addicted. Many factors influence the development of substance use disorders, including developmental, environmental, social, and genetic factors, as well as co-occurring mental disorders. Other factors protect people from developing a substance use disorder or addiction. The relative influence of these risk and protective factors varies across individuals and their lifespans.

Learn More – Fentanyl Addiction Treatment

How Long Does A Heroin High Last?

How long does a heroine high last? The effects of heroin usually occur in two stages. The first is the initial rush of pleasure, warmth, and tingling that users experience when the drug’s effects kick in. This period might last anywhere from a few minutes to many hours, depending on the mode of administration (i.e. injecting, snorting, smoking, or swallowing). The second stage is the high’s continuation, during which consumers experience pain alleviation, relaxation, tiredness, and moderate euphoria. The duration of this stage varies depending on several circumstances, but it normally lasts between 2 and 5 hours.

Heroin is a white or brown powder or a black, sticky goo. It’s an opioid drug made from morphine, a natural substance in the seedpod of the Asian poppy plant. It can be mixed with water and injected with a needle. Heroin can also be smoked or snorted up the nose. All of these ways of taking heroin to send it to the brain very quickly. This makes it very addictive.

Major health problems from heroin include miscarriages, heart infections, and death from overdose. People who inject the drug also risk getting infectious diseases, including HIV/AIDS and hepatitis. Regular use of heroin can lead to tolerance. This means users need more and more drugs to have the same effect. At higher doses over time, the body becomes dependent on heroin. If dependent users stop heroin, they have withdrawal symptoms. These symptoms include restlessness, muscle and bone pain, diarrhea and vomiting, and cold flashes with goose bumps.

Percocet is a prescription painkiller derived from the same source as morphine and heroin. It can cause serious addiction problems. How long does a Percocet high last? or how long does a perc high last? The prescription opioid drugs, such as Percocet, can also produce high effects the same as illicit drugs like heroin. Once someone takes Percocet, the effects normally last for about four to six hours. But overusing Percocet will lead to addiction and may require professional treatment for Percocet addiction recovery.

Opioid Use Disorder

Opioids attach to opioid receptors in the brain, which leads to a release of dopamine in the nucleus accumbens, causing euphoria (the high), drowsiness, and slowed breathing, as well as reduced pain signaling (which is why they are frequently prescribed as pain relievers). Opioid addiction typically involves a pattern of:

  • Intense intoxication
  • The development of tolerance
  • Escalation in use, and
  • Withdrawal signs include profound negative emotions and physical symptoms, such as bodily discomfort, pain, sweating, intestinal distress, and, in the most severe cases, seizures.

As use progresses, the opioid must be taken to avoid the severe negative effects that occur during withdrawal. With repeated exposure to opioids, stimuli associated with the pleasant effects of the substances (e.g., places, persons, moods, and paraphernalia) and with the negative mental and physical effects of withdrawal can trigger intense craving or preoccupation with use.

Get The Facts – Heroin Addiction Treatment
How long does a high last? “The route of use, the dose, and the presence of any contaminants can all affect a “drug high.”

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How Long Does A Cocaine High Last?

How long does a crack high last? or how long does a coke high last? The euphoria from snorting cocaine normally lasts 15 to 30 minutes, but a crack high lasts only 5 to 10 minutes. However, the exhilarating effects of meth often last eight to twenty-four hours.

Addiction to stimulants, such as cocaine and amphetamines (including methamphetamine), typically follows a pattern that emphasizes the binge/intoxication stage. A person will take the stimulant repeatedly during a concentrated period of time lasting for hours or days (these episodes are called binges). The binge is often followed by a crash, characterized by negative emotions, fatigue, and inactivity. Intense craving then follows, which is driven by environmental cues associated with the availability of the substance, as well as by a person’s internal state, such as their emotions or mood.

Stimulants increase the amount of dopamine in the reward circuit (causing the euphoric high) either by directly stimulating the release of dopamine or by temporarily inhibiting the removal of dopamine from synapses, the gaps between neurons. These drugs also boost dopamine levels in brain regions responsible for attention and focus on tasks (which is why stimulants like methylphenidate [Ritalin®] or dextroamphetamine [Adderall®] are often prescribed for people with attention deficit hyperactivity disorder). Stimulants also cause the release of norepinephrine, a neurotransmitter that affects autonomic functions like heart rate, causing a user to feel energized.

Get The Facts – Cocaine Addiction Treatment
How long does a high last? or how long does a mushroom high last? Addictive substance hits everyone differently, so while your high may only last for a couple of hours, you could potentially feel the comedown or aftereffects for several hours or through the next day.

How Long Does A Shroom High Last?

How long does a high last when you consume or use shrooms? How long does a shrooms high last? Shrooms high can typically last between 3 to 6 hours, but the compounds from shrooms can stay in your system up to 14 days after your last use. There are multiple factors that affect how long shrooms last. Continue reading to learn more.

Shrooms can have a wide range of effects, both positive and negative depending on the person consuming them. Knowing how long they last in your system is important to understand the full impact of shrooms usage. The length of time shrooms will remain in your system depends on several factors, including dosage and individual body chemistry.

Shrooms can have a wide range of effects, both positive and negative depending on the person consuming them. Knowing how long they last in your system is important to understand the full impact of shrooms usage. The length of time shrooms will remain in your system depends on several factors, including dosage and individual body chemistry. So, how long do shrooms stay in your system?

How long does a high last when consuming magic shrooms? The short answer is that the effects of shrooms typically last up to 6 hours. But the compounds that shrooms are made from can stay in your system for up to 14 days after your last dose. Your body’s metabolism can affect how quickly shrooms are broken down in your system, so this time frame can vary.

Learn More – How Long Do Shrooms Last?

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Top 4 How Long Does A Smoking High Last? FAQs

  1. How long does a vape high last?

    The peak of vape high could last for about 20-30 minutes, whereas the total effect may last for about three hours.

  2. How long does a blunt high last?

    The high is often strongest for around 10 minutes to half an hour after smoking cannabis, but if you smoke a lot, you may still feel stoned for a number of hours. When you consume cannabis, the peak effects can continue for 2 to 4 hours, and the effects may persist for many hours longer.

  3. How long does a cart high last?

    Smoki



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