According to the American Board of Cosmetic Surgery, Botulinum Toxin injections are one of the most popular cosmetic treatments in the USA. As a professional nurse injector, I adore this procedure because it shows incredible results and makes people admire their reflection in the mirror. I always explain to my patients that we have several available treatments, and Botox is just a trading name for the first registered drug. It is also used as a collective name for all botulinum toxin medications.

In the USA, there are currently five toxin-based treatments approved by the FDA (Food and Drug Administration) toxin-based treatments: Botox, Dysport, Xeomin, Jeuveau, and Daxxify. They are all slightly different and need to be administered only after a professional assessment of every client. The most frequently asked question that interests everyone is the duration of the effect. How long does Botox last? It depends on the work of the individual excretory system and drug of choice. So, keep reading to find out which Neurotoxin product is the most persistent.

How Long Does Botox Last?

Botox

Botox is the good old anti-wrinkle treatment introduced in 1989 and first approved in 2002 for esthetic uses. It is time-tested and deserves the honor of an effective cosmetic product. This drug can work with forehead lines, crow’s feet, and glabella. Compared to Dysport, Botox is more precise, meaning it best suits people with thicker muscles. Best on my professional experience, the average effect of this treatment lasts from 2 to 3 months and can be slightly prolonged if the patient refrains from taking vitamin B complex and avoid massaging the injection site.

Dysport

Dysport is a French brand of botulinum toxin type A approved for esthetic use in the US in 2009. In that distant time, many Botox fans decided to give up on their favorite and replace it with a new drug. So what is good about this “upstart”? You can read our comparison review in this article: “Dysport vs Botox: Which One to Choose?”

Compared to other neurotoxin products, Dysport is more diluted. It contains smaller molecules that can easily spread to the neighborhood areas of the injection site. The best candidates for such treatment are people with fine-to-moderately deep wrinkles on the forehead and between the eyebrows. In general, the effect of Dysport lasts from 4 to 5 months and may last even longer after the second treatment.

Xeomin

Xeomin is a botulinum toxin type A manufactured in Germany by the pharmaceutical company Merz. It was approved by the FDA in 2011 to treat moderate to severe frown lines between the eyebrows. The fundamental difference between Xeomin and other neurotoxin drugs is the absence of complex proteins. This means it has a more purified formula and is less likely to lead to desensitization and minimize the risk of allergic reactions. Besides, Xeomin provides a softer effect on the muscles, which allows you to maintain natural facial expressions. 

Considering all these features, I recommend it to people with less prominent wrinkles or those who have allergies because it is the softest and safest neurotoxin in the US market. That sounds like we found the best treatment option, but it’s not that simple. Sometimes advantages come with some nuances. As the softest neurotoxin, Xeomin can stay on the face for 1 to 3 months. Indeed, it depends on the individual, but I’m drawing a conclusion based on my experience with this drug.

Jeuveau

Jeuveau is a Korean wrinkle relaxer made by Evolus. It was approved by the FDA in 2019 and has already shown its best side. This drug costs slightly cheaper than other toxin-based medications. Most people call it “NewTox” because it contains the same active ingredient as Botox.

Unlike all previously discussed neurotoxin products, Jeuveau can only be used to ease the appearance of frown lines between the eyebrows. There is no official indication of how long its effects last, but on average, it is pretty similar to Botox, meaning it lasts from 2-3 months.

Daxxify

Daxxify is the newest American neurotoxin treatment made by Revance Therapeutics Inc. in Nashville. Based on the three clinical trial programs, the effect of this drug can last from 4 to 6 months, meaning it is the most persistent neurotoxin. It is approved by FDA for smoothing the lines between the eyebrows but isn’t yet available in the market. We keep our fingers crossed and hope to see it in 2023.

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