Eating less and moving Greater are the fundamentals of weight loss that lasts. For some people, Prescription weight loss tablets may additionally assist. Greater commonplace prescription weight loss capsules that have been in use longer include: liraglutide (saxenda), naltrexone-bupropion (contrave), orlistat (alli, xenical), phentermine (adipex-p, ionamin, seasoned-speedy), and phentermine-topiramate (qsymia). Earlier than you get a weight reduction drug prescription, inform your doctor about your clinical history. Naltrexone hcl and bupropion (contrave)how it works: contrave is a combination of fda-accredited drugs, naltrexone and bupropion, in an prolonged-launch method.