Drug delivery in a selective manner to a biological target, such as an organ, tissue, cells, or intracellular organelles, is called targeted Drug delivery. Targeted drug delivery is achieved by ensuring high drug concentration in a target organ or tissue through the systemic circulation. In other words, a drug is delivered systemically or is absorbed into the systemic circulation, first—before accumulating at the target site of action. This modality is exemplified by the intravenous administration of a liposomal delivery system of a cytotoxic drug such that the drug distribution into the kidney is avoided, thus minimizing the renal side effects of the drug.