Doxycycline acts bacteriostatically by binding with ribosomes and thus inhibiting the bacterial protein synthesis. In high doses it is also detrimental to the protein synthesis in human cells. Like other tetracycline, Doxycycline is a Broad Spectrum Antibiotic and it is active against a very large number of microorganisms
Indication
Asdoxin is indicated in the treatment of respiratory tract Infections, urinary tract infections, sexually transmitted diseases, dermatological infections, ophthalmic infections and rickettsial infections.
Dosage
Adult: on the first day of treatment, 200 mg/day is recommended. The treatment followed by 100 mg/day. Administration of both doses may be given as single dose or multiple doses. In case of severe infections like chronic infections of urinary tract 100 mg/every 12 hours is recommended. Doxycycline capsules should be given with plenty of fluid, with the patient in upright position and well before retiring to bed. It may be given with food or milk if gastric irritation occurs
Children: not recommended
Contraindications
Asdoxin is contraindicated in patients with rare hereditary problems of fluctose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency. Use of drugs of the tetracycline class drugs during tooth development may cause permanent discolouration of the teeth (yellow-grey-brown). Enamel hypoplasia has also been reported. Doxycycline is therefore contraindicated in these groups of patients and in children under the age of 12 years
Adverse effects
- Gastrointestinal disturbances
- Tooth discoloration
- Oseophagal ulceration may be particular if capsules are taken with insufficient fluid or recumbent posture
- Anosmia
Pregnancy: doxycycline is contraindicated during pregnancy
Lactation: tetracyclines are excreted into milk and are therefore contraindicated to nursing mothers
