A Mutation in the PLCG2 gene protects against various forms of Dementia. Carriers of this mutation have a greatly increased chance of turning 100 without dementia. This finding is the result of genetic research conducted with no less than half a million of hundred-year-olds worldwide.

PLCG2 is part of the immune system in the brain, suggesting that dementia is a result of faulty immune function in patients.

Researchers now try to determine why PLCG2 protects against dementia, so that this effect might be mimicked by medication in the future.

Read the full story: Amsterdam UMC (in Dutch)
Scientific publication: Acta Neuropathologica