According to the latest expert opinions, it looks like the human body has its own built-in Ozempic. Check out the latest reports about this below.
New discovery about the human body
Wegovy, Ozempic, and Mounjaro are Drugs that have generated a lot of interest in the health industry due to their effectiveness in weight loss and diabetes control.
These drugs target regulatory pathways involved in obesity and diabetes, making them a breakthrough in managing these conditions. But what led to the development of these drugs and do they offer a solution to the root cause of metabolic diseases?
It turns out that the body produces natural versions of these drugs, known as incretin hormones, in the gut. These hormones are regulated by nutrients in Food, and the trillions of microbes in the gut play a crucial role in this process.
Specialized bacteria in the lower gut break down components of food such as fiber and polyphenols, which are removed in most processed foods, and transform them into molecules that stimulate hormones to regulate appetite and metabolism.
This includes GLP-1, a natural version of Wegovy and Ozempic.
GLP-1 and other hormones, such as PYY, play an important role in regulating blood sugar levels through the pancreas.
Additionally, they signal to the brain when you feel full and tell the stomach and intestines to slow down the digestion process to allow for proper digestion. This system is known as the colonic brake.
In the past, a diverse healthy gut microbiome was responsible for regulating metabolic pathways and appetite through these hormones. However, modern food processing techniques that aim to improve the taste and shelf life of food have removed essential bioactive molecules like fiber and polyphenols that help regulate this system.
As a result, the decrease in gut microbiome diversity due to the removal of key food components may be a significant contributing factor to the increasing rates of obesity and diabetes.
Incretin-based therapies are often seen as a solution to many problems, but they have some side effects on the gastrointestinal system such as nausea, vomiting, diarrhea, and constipation.
These issues result from the drugs’ ability to slow down the digestive system. In addition, more severe side effects such as inflammation of the pancreas and stomach paralysis are also possible, although they are rare.
These drugs may lead to a loss of healthy lean muscle mass as well as fat, especially if there is no exercise. Furthermore, significant weight gain after discontinuing the drugs raises questions about their long-term effects and whether it is possible to rely solely on lifestyle measures to manage weight.
To address the obesity and metabolic disease epidemic at its core, it is essential to reintroduce minimally processed foods into your diet, particularly those rich in fiber and polyphenols such as flavonoids and carotenoids. These foods can play a vital role in complementing the effects of medication.
We suggest that you check out the latest reports about this in Scientific American.
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