I'm sure that everyone has thought about the meaning of a particular metaphysical proposition for their own lives. I rather like Marcus Aurelius on this:

Either things must have their origin in one single intelligent source and all fall into place to compose, as it were, one single body- in which case no part ought to complain of what happens for the good of the whole- or else the world is nothing but atoms and their confused minglings and dispersions. So why be so harassed?

The argument is of course very comforting! Its also interesting that those are the alternatives- picking up on an earlier post they look still like alternatives that seem real to us today.