Brain tumours are scary and very difficult to deal with, current treatments include invasive surgery and/or radiation. The advent of mRNA based vaccines is making a difference in how we can treat various brain cancers and the early results are looking promising. A team just found a way to get the body’s immune system to start to find and address cancer within the brain. While the results are not yet usable the outlook is very promising.

“The demonstration that making an mRNA cancer vaccine in this fashion generates similar and strong responses across mice, pet dogs that have developed cancer spontaneously and human patients with brain cancer is a really important finding, because oftentimes we don’t know how well the preclinical studies in animals are going to translate into similar responses in patients,” said Duane Mitchell, M.D., Ph.D., director of the UF Clinical and Translational Science Institute and the UF Brain Tumor Immunotherapy Program and a co-author of the paper. “And while mRNA vaccines and therapeutics are certainly a hot topic since the COVID pandemic, this is a novel and unique way of delivering the mRNA to generate these really significant and rapid immune responses that we’re seeing across animals and humans.”

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