CARACAS, Venezuela—January 23, 2019— Venezuela’s crisis quickly escalated Wednesday as an opposition leader backed by the Trump administration declared himself interim president in a direct challenge to embattled socialist Nicolas Maduro, who retaliated by breaking off relations with the United States, his biggest trade partner.

For the past two weeks, ever since Maduro took the oath for a second six-year term in the face of widespread international condemnation, the newly invigorated opposition had been preparing for nationwide demonstrations Wednesday coinciding with the anniversary marking the end of Venezuela’s last military dictatorship in 1958.

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