BYHALIA, Miss. — An Alabama tour bus bound for a Mississippi casino overturned Wednesday on an icy highway, leaving two people dead and 44 others aboard with injuries, authorities said, as a pre-winter Storm blasted parts of the South and lower Midwest.

The National Weather Service says snow and ice fell during the day across parts of Mississippi, Arkansas, Tennessee, Missouri, Kentucky, Indiana and Illinois. Snow and ice are predicted Thursday and Friday for areas ranging from Ohio and the Appalachian Mountains through Washington, D.C., New York and New England from the storm barreling toward the Northeast.

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