Try the businesses making headlines earlier than the bell:

Toyota (TM) – Toyota gained 2.2% in Premarket buying and selling, after asserting it might produce a document 800,000 automobiles in January. Toyota is ramping up output to make up for prior manufacturing misplaced to components shortages.

Vir Biotechnology (VIR) – Vir Biotechnology is rallying 4.3% within the premarket, placing it in place to rise for a fifth straight day. The drugmaker introduced additional information displaying that its Covid-19 antibody remedy – developed in partnership with GlaxoSmithKline (GSK) – was efficient in opposition to the omicron variant.

Eli Lilly (LLY) – The drugmaker raised its 2022 revenue and income forecast forward of as we speak’s assembly with the funding neighborhood, noting that it’s on observe to fulfill its purpose of delivering 20 new therapies within the 10-year interval by way of 2023. Lilly moved greater by 4.7% within the premarket.

RR Donnelley (RRD) – RR Donnelley agreed to be acquired by Chatham Asset Administration – the printing firm’s prime shareholder – for about $897 million. Donnelley terminated an earlier buyout deal it reached with non-public fairness agency Atlas Holdings after figuring out that Chatham’s bid was a “superior proposal.” The inventory fell 2.8% within the premarket.

Domino’s Pizza (DPZ) – Domino’s fell 2.1% in premarket buying and selling after Barclays downgraded the inventory to “underweight” from “equal weight.” Barclays stated stable fundamentals and Covid headwinds within the trade as an entire helped Domino’s outperform in the course of the pandemic, however famous that these headwinds for its rivals at the moment are fading.

Regeneron Prescription drugs (REGN) – Regeneron was downgraded to “market carry out” from “outperform” at Bernstein, which cites the danger to Regeneron’s best-selling eye drug Eylea from the long run launch of biosimilars. Regeneron slid 1.8% within the premarket.

Six Flags (SIX) – The theme park operator’s inventory rose 2.2% within the premarket after Goldman Sachs upgraded it to “purchase” from “impartial,” noting resilient ticket pricing in addition to steering from Six Flags that Goldman considers conservative.

Hostess Manufacturers (TWNK) – The maker of Twinkies and different snack meals was rated “purchase” in new protection at Citi, which stated Hostess is exiting the pandemic in a powerful place with innovation driving market share beneficial properties. Hostess was up 1.1% within the premarket.

United Parcel Service (UPS) – UBS named the supply service’s inventory as a “prime decide,” saying UPS ought to profit from elevated shopper spending and that it has a higher probability of margin enlargement than its rivals. UPS rose 1.1% in premarket buying and selling.

CMC Supplies (CCMP) – The superior supplies provider agreed to be acquired by rival Entegris (ENTG) in a cash-and-stock deal. Based mostly on Tuesday’s closing costs, the transaction is value $197.53 per CMC share, in contrast with CMC’s Tuesday shut of $145.97. Entegris fell 3% within the premarket.

Bloomin’ Manufacturers (BLMN) – The Outback Steakhouse guardian surged 5.3% in premarket buying and selling after Jefferies added the inventory to its “franchise picks” checklist, saying the corporate was positioned to profit from constructive structural modifications within the informal eating class.