In this modern era where everyone is looking for ways to look fit and muscular, more supplements in the form of peptides are coming up in the market to meet customer demands. 

Scientists are finding more ways to utilize the already present biomolecules and form derivatives with enhanced effectiveness and potency. 

One such peptide is HGH-FRAG 176-191.

It is a derivative version of a naturally found Human Growth Hormone that has been modified in several ways for better and faster results. 

This article explains everything you need to know about HGH-FRAG 176-191, all the way from its molecular composition to its benefits, possible side effects, dosages, legality, and the best vendor to buy from. 

What Is HGH-FRAG?

HGH-FRAG is a sliced version of Human Growth Hormone. Distinctly it comprises the last 16 amino acids sequence of HGH from the 191-long sequence of the latter. Chemically the peptide goes by C39H60N8O13 (1). 

However, unlike HGH, the HGH-FRAG has quite a different working mechanism. One would think that being a spliced part of Growth Hormone, HGH fragments would also be conventionally working the same way. Nevertheless, the answer is no. 

Unlike its parent GH, HGH-FRAG does not bind to Growth Hormone Receptors (GHR) because it does not consist of all 191 amino acids. Thus, it can neither transcribe the formation of IGF-1 nor carry out any anabolic functions the way GH would. 

So, what does HGH-FRAG 176-191 do after all? 

Well, it has retained the lipolytic properties of GH. Henceforth, the HGH-FRAG peptide is most frequently used to carry out desired lipid metabolism functions. 

How Does HGH-FRAG Work?

The working mechanism behind HGH-FRAG is still not fully understood and subjected to numerous criticism in the scientific community. However, there are three main areas where HGH-FRAG showed superlative effects. Let’s look into these research-backed mechanisms and gain more insight into how HGH-FRAG 176-191 got so welcomed worldwide. 

HGH-FRAG, unlike Growth hormone, does not retain all the properties of its parent biomolecule. Rather, it took one great attribute, i.e., lipolysis. HGH-FRAG 176-191 practical use in obese mice has resulted in an increased formation of beta-3 adrenergic receptors in fatty tissues. (2) 

These receptors are involved in fat mobilization and utilization in adipose tissue and are also found to mediate the thermogenesis process in muscles, especially the skeletal muscles. 3) 

Research also suggests that a three-week course with HGH-FRAG therapy in obese mice resulted in an approximate cut down of 50% in weight gain. (4) 

Interestingly, HGH-FRAG 176-191 therapy only ensued in obese/weight mice. It didn’t cause any significant weight loss in an average-weighted mouse. (2)  

Another possible mechanism of action followed by HGH-FRAG is its property to cause hypoglycemia due to its C-terminal. Scientists began researching whether the same hypoglycemic attributes were found in the fragments of HGH or not. 

One such fragment was 176-191. The peptide fragment could potentially decrease blood glucose levels (5) and thus can technically be used in the treatment regimen of pre-diabetes and diabetes mellitus type 2 (DMT2). 

However, more meta-analysis and clinical trials on a much larger scale are needed for any of the above mechanisms to be stated with hard core evidence. 

More authentic research is being done on knowing and investigating the possible effects of HGH-FRAG 176-191 on cartilage regeneration and growth. In experiments, the use of HGH-FRAG alongside Hyaluronic acid injections in rabbits increased the cartilage growth to substantial levels. (6) 

Scientists believe that increased and legitimate investigations in this matter can further unfold the idea of using HGH-FRAG 176-191 in treating osteoarthritis and minimizing surgery. 

Benefits of HGH-FRAG

HGH-FRAG has been in the market for a long time and has been subjected to repeated clinical trials before it ever got into the hands of the general populace. 

Some of the research-backed benefits of HGH-FRAG 176-191 include the reduction of fat reserves without any severe side effects, inhibiting lipolysis, increased energy levels, strengthening and build-up of muscle mass, and substantial decrease in obesity. 

Because HGH-FRAG regulates blood glucose levels, it can be said that it mitigates the risk of developing any cardiometabolic disorders, such as Type 2 Diabetes Mellitus (T2DM). 

It is also believed that it does not alter the IGF-1 serum levels or interact with other body mechanisms. 

It can also be used to increase bone density and upregulate muscle recovery, thus affecting your overall musculoskeletal system. 

Is HGH-FRAG Legal?

The legality of HGH isn’t a straightforward answer. HGH is currently prohibited by the World Anti-Doping Agency, which monitors the fight against drugs in sports. 

In the United States, HGH is completely illegal to be distributed or prescribed by physicians for reasons other than the ones already approved by FDA. 

In children, HGH Fragment therapy is legal to be used in cases of poor and stunted growth in cases of Turner’s syndrome, Prader-Willi syndrome, chronic renal insufficiency, and hGH insufficiency. In adults, however, the use is limited to be used for treating wasting syndrome of AIDS and hGH deficiency. 

However, according to sources, HGH-FRAG 176-191 isn’t a regulated peptide. Thus, one can find the peptide in authentic online stores or peptides, unlike Human Growth Hormone (HGH), which is FDA regulated and legal in only certain medical conditions

Who Should Use HGH-FRAG?

HGH-FRAG is most commonly used by people looking for effective yet rapid ways to reduce weight. Thus, fitness enthusiasts are the most usual and frequent users of HGH-FRAG peptides. 

However, if you’re allergic to certain components that the peptide might contain, get in contact with your primary physician before starting your journey with HGH-FRAG. 

What’s worth mentioning here is that the HGH-FRAG peptide is different from the Human Growth peptide, with the latter having side effects and legal restrictions.

HGH-FRAG Dosage

The optimal dosage differs from person to person and is also heavily dependent on why HGH-FRAG therapy was started. However, according to sources, HGH-FRAG can be divided into three categories based on needs and tolerance. 

For beginners, 200 mcg of HGH-FRAG is recommended in the morning before breakfast and 200 mcg pre-training. This should be continued 5 to 7 weekly via subcutaneous injections for favorable outcomes. 

The dosage can be increased to 250 mcg and 300 mcg for intermediate or advanced levels, respectively. 

One needs to ensure that for multiple dosages, the administration with HGH-FRAG should be given with a minimum of 3-hour gap in between to prevent any distressing side effects.

HGH-FRAG Cycling

With the right dosages and proper administration of HGH-FRAG, the cycling of the peptide should be done for approximately four to eight weeks. 

However, it is primarily dependent on the desirable results. 

Nonetheless, the cycle of HGH-FRAG 176-191 should not last more than 12 weeks at the max. 

Forms Of HGH-FRAG?

HGH-FRAG is most commonly found only in injection forms. It is very unlikely for any brands to offer peptide in the form of powder, pills, or capsules. 

How To Use HGH-FRAG?

HGH-FRAG is usually given via intravenous, subcutaneous route instead of pills or capsules. 

A typical protocol can include injecting HGH-FRAG 250 to 500 mcg per injection 1 to 2 times daily. 

However, make sure that HGH-FRAG injections are given on an empty stomach. Thus before breakfast and pre-lunch timings are the most appropriate. 

HGH-FRAG Side Effects

Supplementation with Human Growth Hormone comes off with its side effects and health concerns. Misuse, overdosing, or wrong timing of any medications has its fair share of repercussions. 

With Human Growth Hormone, the side effects might be severe. These include joint inflammation, increased risk of predisposition to diabetes because of decreased insulin sensitivity, and carpal tunnel syndrome due to inflamed joints. Besides this, increased doses of growth hormone can lead to decreased or difficulty in having proper schedules. 

Nevertheless, the HGH-FRAG 176-191 is specifically designed to avoid any side effects and is instead full of benefits. Minor side effects such as rashes or swelling on the injection site can be common. 

HGH-FRAG Reviews

One of the best ways to know and gather unbiased information without malice or intrusion is to look for customer reviews. These user reviews can help one decide better whether they want their money to be utilized in products that look all shiny and glowy but have question marks regarding their quality and authenticity. 

For that matter, I skimmed different subreddits to actually get an accurate insight. I have included a few Reddit reviews for you to decide better on HGH-FRAG 176-191. 

One such user said,

“Tried and had good results, lower back fat decreased (was already lean but the lower back is very stubborn). Real is hard to find, though.”

Others faced some issues with their HGH-FRAG supplementation and said, 

“My same experience as well. Didn’t notice any fat loss benefit. No PCT or sides.”

“I’ve tried this compound a few times.. I honestly… don’t rate it. My Diet was on point and my results were due to my training and dieting. I feel like it didn’t really work too well for me.”

HGH-FRAG Stack

HGH-FRAG can work effectively on its own as well. However, stacking it with other compounds is proved to be efficacious and productive. Let’s look at some stacks you wouldn’t want to miss. 

Liquid Growth Hormone + HGH-FRAG 176-191

This is one of the most popular used stacks around the globe. HGH-FRAG and the human growth hormone help increase muscle mass side by side, assisting in lipid metabolism and reducing fat reserves. 

It is particularly important for people who haven’t had the chance to increase their muscle mass. For the right dosage and optimal results, five units of Liquid Growth hormone and 1000 mcg of HGH-FRAG (divided into 3-4 injections) would be a good start. 

GHRP-6 + HGH-FRAG 176-191 + Melanotan 2

This stack is usually used by those looking for a way to increase their overall energy and reduce fat from their body. GHRP-6 Peptide is believed to regulate your appetite. This helps you gain more strength and energy. 

The cycle should last eight weeks for this stack, with all the components being taken together. 100 mcg of GHRP-6, 250 mcg of HGH-FRAG 176-191, and approximately a single dose of Melanotan 2 at 1mcg per 1 kg of body weight are recommended specific results. 

Nonetheless, get yourself in touch with your physician to get proper and reassured dosages. 

Where to buy HGH-FRAG?

Owing to some legal issues, you may not be able to find HGH-FRAG very commonly at stores. Therefore, I have tried to pick the 2 best vendors selling the peptide online so that you can possibly make your purchase without any worries. 

HGH-FRAG vs Other Compounds 

HGH-FRAG vs HGH

Human Growth Hormone (HGH) is a native hormone in human serum comprising 191 amino acids. It is an essential hormone that regulates many different mechanisms in humans. 

Compared to HGH, HGH-FRAG 176-191 is a peptide fragment composed of the last 16 amino acids of HGH. The peptide does not contain all the properties of its parent. Rather the derivative is laded with lipolytic properties as backed by most research. 

HGH-FRAG vs Ipamorelin

Ipamorelin peptide therapy is often used to increase your body’s own ability to produce human growth hormone naturally. This way it aids in the reduction of body weight alongside in increasing the lean muscle mass. 

Ipamorelin is much more tolerable due to letting your own body produce growth hormone instead of replacing it. Thus it is much safer than synthetic growth hormone peptides such as HGH-FRAG. 

Is HGH-FRAG Legit? 

All in all, it can be deduced from all the above information that HGH-FRAG is legitimate and henceforth, it can be used to reduce the overall body fat by increasing lipid metabolism, increasing lean muscle mass, and also assisting in maintaining energy homeostasis. 

With HGH-FRAG 176-191 there are very low chances of developing any severe side effects, unlike the synthetic HGH. Thus, you’re in safe hands with this peptide.