Enroll at Kings International Medical Academy to excel in the FMGE 2023
Kings International Medical Academy is renowned as a leading coaching centre for FMGE, consistently achieving outstanding results. Our exceptional track record in FMGE speaks for itself and demonstrates our excellence. We are honoured to have Dr. V.S. Kumar, a highly esteemed faculty member, deliver an engaging lecture on the subject of Biochemistry at Kings International Medical Academy. Today, let’s delve into the topic of “Cholesterol Synthesis.”
Cholesterol Synthesis
- Cholesterol is Amphipathic in nature
- 27c
Synthesis: occurs in all tissues- contain nucleated cells
Organs: Liver, Adrenal corlex, ovaries, testis
Organelle: SER/ Cytoplasm
Starting point: Acetyl COA
Regulation of Cholesterol Synthesis:
- Feedback inhibition: RLE- HMG-COA Reductase- Cholestrol & mevolonate (acts via sterol regulating element, binding protein)
- Hormonal Regulation:
Insulin & Thyroxine:
(dephosphorylated)
↑ Activity of RLE, + Chol. Syn.
Glucogon:
(phosphorylated)
↓ Activity of RLE, – Chol. Syn.
Cholesterol Synthesis:
HDL:
- tissue → Liver
Free cholesterol- active
Ester- storage
Reverse cholesterol transport:
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