Cagayan province is blessed with vast flora with presence of many island species that are endemic. Currently, different botanicals have been formulated as pharmaceutical agents to developed new products essential for human wellbeing. This study generally aimed to determine the secondary metabolites present in the three island Endemic Plant Species in Cagayan namely; Igem dagat (Podocarpus costalis C. Presl), Balingagta (Drypetes falcata Pax & K. Hoffm.) and Babuyan lunas (Lunasia babuyanica Merr.) and to determine their hypoglycemic effect on Sprague Dawley Rats. Ethanolic leave extract of the three endemic plant species were used and tested for its phytochemicals. Complete randomized design (CRD) was used for the hypoglycemic potential with three replications for each species and Alloxan was used to induce hyperglycemia in the rats. The results reveals that P. costalis, D. falcata and L. babuyanica contains alkaloids, flavonoids, glycosides, tannins and tripertenes. Likewise, L. babuyanica and D. falcata were also positive with saponin and phytosterols. Analysis of variance (ANOVA) for the initial glucose level, after Alloxan induced and after treatment of plant extracts did not show significant difference across treatment means. Among the treatments, T3 (L. babuyanica ethanolic leave extract) significantly reduced the Alloxan induced hyperglycemia in Spraue Dawley Rats. Glucose level were reduced with the administration of the other treatments but not significant to reject the null hypothesis. All the plant extracts have hypoglycemic effect however, T3 (L. babuyanica ethanolic leave extract) is more effective.

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