What Are Other Functions Of The Liver In The Body – The Liver wants you to know that it’s a really big deal. It is the largest gland in the body, performing over 500 important body functions and is the only organ with the ability to regenerate. It resides above and on the right side of the abdomen and below the lungs and weighs about 3.5 pounds, the second largest organ after your skin.1

And if that’s not impressive enough, your liver is also connected to everything you eat, drink, breathe or absorb into your bloodstream. It functions primarily as the body’s detox mechanism, making it critical to your overall health, including proper metabolism and hormone function.2 Of course, if you’ve been following my blog, you’re already aware of these facts and what happens when the liver isn’t doing its job. Today we are focusing specifically on the liver’s role in hormone function and what that means for those with thyroid dysfunction.

What Are Other Functions Of The Liver In The Body

There are many different players involved in the conversion of T4 (inactive thyroid hormone) to T3. About 20% of this conversion occurs in the intestine via intestinal sulfatase. Leaky gut interrupts this conversion process and causes T3 levels to be lower than normal.3 Likewise, the liver also accounts for 20% of this conversion from T4 to T3. If the liver is not functioning properly, it not only slows down the conversion process, but it also impairs the body’s ability to process and eliminate environmental toxins, allowing the flow of toxins to remain in the body and affect other vital organs, including the thyroid gland. This can raise autoimmune thyroid conditions like Hashimoto’s disease.4 I cover T4 to T3 conversion in great detail and give you a way to increase T3 levels in my book The 30-Day Thyroid Reset Plan.

Liver Histology: Structure, Cells And Characteristics

Now we leave the liver for a moment. Ladies, join me for this short break to discuss our primary sex hormone. Estrogen clearance is the body’s ability to break down estrogen and remove it from the body. This might sound like a lot of work, and yes, it means you’re at least reading from the beginning to this point! Estrogen that is not efficiently metabolized and eliminated can become very toxic

I’m not talking about the strong, independent women I know you are here. Estrogen dominance actually refers to elevated estrogen levels or hormone imbalances that can occur in both men (testosterone/estrogen) and women (progesterone/estrogen). Typical symptoms of estrogen dominance in women include: thyroid dysfunction/nodules, decreased libido, irregular periods, breast tenderness, fibrocystic breasts, fogginess, insomnia, fatigue, weight gain, irritability, depression, cellulite, headaches (usually associated with PMS), and decreased metabolism. Men may also experience some of the above symptoms, but they may also notice larger hips, breast development, and mood changes, including excessive crying and decreased testosterone.5

Unfortunately, our modern lifestyle exposes us to estrogen dominance. Chronic stress, obesity, poor diet, lack of exercise, use of birth control/hormone replacement therapy, environmental estrogens and others can all lead to elevated estrogen and/or hormone balance.

The adrenal glands are a primary player in the endocrine system, involved in our ability to deal with stress by releasing cortisol (the stress hormone) into the bloodstream. Long-term, elevated cortisol levels ensure that the liver is unable to remove estrogen efficiently. Elevated cortisol also leads to progesterone depletion through a process called “pregnenolone stealing.” Pregnenolone, a precursor to progesterone, is diverted from sex hormone production to be used to increase the stress hormone. This increase in estrogen caused by liver dysfunction combined with a decrease in progesterone leads to the signs and symptoms of estrogen dominance.5 This can all be caused by stressful events such as dissatisfaction with your job, dissatisfaction with a relationship, or even stress. which is not emotionally driven like intestinal infections, viruses and more.

What Does My Liver Do? Liver Functions & How To Keep Yours Healthy

In the same way, fat cells have an enzyme that can convert cortisol into estrogen – estrogen is stored in fat. When you lose weight, you have more estrogen in your bloodstream, causing temporary estrogen dominance until your liver can clear it. In men, the aromatase enzyme in body fat converts testosterone into estrogen. Increased body fat levels lead to increased aromatase and therefore increased estrogen levels

Unfortunately, heading to the middle of the grocery store and loading up on packaged and processed foods increases the amount of estrogen-mimicking substances that lead to elevated estrogen levels.6 So do eating habits such as skipping breakfast and high sugar and caffeine consumption. throughout the day, also affects our ability to manage stress and is likely to lead to an estrogen-dominant state. If you skipped the Chronic Stress section above, now would be a good time to return to the page! Caffeine generally increases the release of estrogen and causes depletion of magnesium, vitamin C and B vitamins, which are key nutrients for the liver to remove toxic substances from the bloodstream.

Regular exercise improves estrogen clearance by increasing metabolism, minimizing fat storage, balancing blood sugar levels (improving our ability to cope with stress) and reducing the risk of breast cancer. Lack of exercise can also lead to an increased risk of depression, weight gain, poor digestion, and decreased energy, in addition to making us more susceptible to estrogen dominance.5

In conventional hormone replacement therapy, a hormone supplement containing only estrogen is typically prescribed without the addition of progesterone. If you absolutely want to stay in an estrogen dominant state, this is a really simple way to do it! But before you do, check out the list of estrogen dominance symptoms above. It is very important that you decide on the right combination of hormones for you, so before you try anything, talk to a healthcare professional who can help you make the best choice for your body, especially if you also have thyroid issues.5

Solution: Liver Function Tests

Xenoestrogens are chemicals found in our environment that mimic estrogen once in our body and give our liver a lot of time, especially if we’re also stressed, don’t have time to cook or exercise, and aren’t at an appropriate BMI. . Continuous exposure to these xenoestrogenic compounds prevents our bodies from efficiently eliminating excess estrogen. There are many industrial chemicals, including plastics, especially when exposed to heat or acid, household products (detergents, cleaners), personal care products (nail polish remover, surfactants in condoms and birth control gels) and some makeup/perfumes that act as estrogen once in our bodies. Accumulation of heavy metals is another thing to consider. Excess mercury, lead, and aluminum, such as dental fillings, cans, and processed foods, can inhibit liver function, resulting in poor toxin filtration and high estrogen levels in the blood.5, 6

You guessed it: too much estrogen has a sensitive effect on the thyroid gland. Increased estrogen makes too much thyroid-binding globulin (TBG), a protein that carries thyroid hormones throughout the body through the bloodstream. Thyroid hormones bind to excess TBG, resulting in a deficiency of thyroid hormones that are used by the cells, presenting as hypothyroidism. Hypothyroidism also leads to the fact that the production of sex hormones is not appropriate

To properly remove excess estrogen from the bloodstream, the estrogen must be made water-soluble so it can be excreted through sweat, urine, or feces. There are two pathways in the liver that make this happen:

Phase I pathway – the fat-soluble molecule (in this case, estrogen) enters the liver. The liver changes the chemical structure of the molecule to prepare it for excretion.

Why Is The Liver So Amazing? · Frontiers For Young Minds

Phase II pathway – Additional molecules from Phase 1 are added to the modified compound so that it can be safely removed.

If these pathways are not working efficiently, estrogen circulates back into the bloodstream in a more toxic form that cannot be cleared.5

And sometimes, no matter what you try, your body just needs a little extra support to achieve better liver, gut and thyroid harmony. I recommend Liver Love as a supplement to anyone struggling with thyroid imbalance, autoimmune disease, elevated cortisol, poor blood sugar control, slowed bowel function, or other liver or kidney disease. It is a synergistic formula designed to support healthy liver function. It contains a mixture of herbal substances and mushroom extracts, as well as N-acetyl-L-cysteine ​​and milk thistle, both of which have strong antioxidant and liver-protective functions.

This is a powerful antioxidant precursor that neutralizes free radicals and prevents the accumulation of toxins.7 NAC has been shown to improve insulin sensitivity and help avoid post-meal blood sugar spikes and crashes, which can help your body promote healthy stress. answer. Because of this, NAC also has a function in the prevention of autoimmune problems.8

Liver Anatomy And Physiology: Video & Anatomy

Milk thistle contains a powerful antioxidant compound known as silymarin. One study found that silymarin increased glutathione (its precursor is NAC) in the gut and liver by up to 50%.9  Salymarin also protects the body from gamma radiation, which can be a significant risk factor for certain cancers and thyroid disorders. .10

I think sometimes people just assume stress management, eating

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