Seattle, WA, USA
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow.
A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, Viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin (Nature 2016, J. Virol 2017, Mol Cel Proteomics 2017). Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.
Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.
The successful candidate will work on collaborative projects in the Avgousti Lab primarily focused on, but not limited to, the understanding the dynamics of protein VII-DNA complexes, protein VII-nucleosome complexes, binding partners and the impact of mutations on viral infection. Candidates should have excellent communication skills, value teamwork and can thrive in a fast-paced environment.
We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Preference will be given to candidates with a background in structural biology for the study of viral proteins by crystallography or other biophysical techniques. Virology knowledge is beneficial but not required.
Interested candidates should submit a CV, a summary of research experience and interests, and contact information for three references.
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