Semax is a peptide that researchers are studying for its potential to Improve Cognitive Function and protect the brain. It has been researched in Russia and Ukraine as a treatment for brain injuries and alcohol-related neurotoxicity. Early studies suggest Semax may improve attention, memory, and have general nootropic effects. It may also protect nerves.
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Semax was originally developed in the Soviet Union as a potential therapy for stroke, head trauma, neurodegenerative diseases like Alzheimer’s, Parkinson’s, and Huntington’s. As a neuropeptide, it is thought to act on the central nervous system and have neuroprotective, neuroregulatory, and neurotrophic properties. Chemically, it is a synthetic analog of the melanocortin adrenocorticotropic hormone (ACTH) fragment 4-10. The peptide is comprised of seven amino acids.
Research has looked at Semax’s potential in models of ischemic injury, suggesting it may shorten recovery time and improve outcomes. Its nootropic-like effects on attention and memory have also been studied. Beyond neuroprotection, there is interest in Semax’s potential immune and mood effects. In ischemia models, Semax with ADP and collagen appears to alleviate symptoms, with calcium responsible for mediating ADP’s effects. Semax may act through both neurotrophic and antiplatelet mechanisms in chronic brain ischemia.
Studies of Semax in alcohol delirium models showed reduced asthenic issues, autonomic/neurologic abnormalities, and improved cognition over time. Semax is being studied in this context due to its potential anti-hypoxic effects, with the goal of improving cognition and preventing encephalopathy.
Regarding infection, Semax may activate neutrophil respiratory burst in conjunction with PMA. Neutrophils release reactive oxygen species to combat bacteria/pathogens, known as respiratory burst. So Semax may boost this effect.
Clinically, Semax has been found to possibly accelerate ulcer healing when combined with basic ulcer therapy, improving healing rates versus basic therapy alone. Researchers interested in studying Semax further should obtain it from licensed sources, as these compounds are not approved for human/animal use outside research settings.
