I have started observing a new phenotype of opioid/xylazine Addicts - limb amputations (be it autoamputation or surgical) and severe cachexia with multiple complex wounds. 

This is of course if they make it out of the ICU after being on incredible amounts of sedation for their megawithdrawal.

It's absolutely horrifying. I've been consulted on these patients I think largely because they are so distressing to witness by the medical/nursing teams. They usually have some amount of life-limiting illness potential because of consequences of their addiction, and many of them leave AMA or don't engage with long-term treatment so you're just kind of pleading with them to try and stay in treatment so they don't destroy themselves in a visually impressive manner.