If you’re looking for the best bet to make among the 16 NFL games in Week 1, we’re going with the Packers at +1 in terms of the point spreads. Don’t stop there, though — scroll down, because we have lots more tips, which you could use in a parlay.

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Best Week 1 Spread Bets

Pick: Green Bay +1 vs. Chicago

• Matchup: Green Bay Packers at Chicago Bears
• Projected Favorite & Spread: Green Bay by 6.4 points
• Time: 4:25 PM ET
• Date: September 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo

Pick: Cincinnati -2.5 vs. Cleveland

• Matchup: Cincinnati Bengals at Cleveland Browns
• Projected Favorite & Spread: Cincinnati by 8.8 points
• Time: 1:00 PM ET
• Date: September 10
• TV Channel: CBS
• Live Stream: Watch this game on Fubo

Pick: San Francisco -2.5 vs. Pittsburgh

• Matchup: San Francisco 49ers at Pittsburgh Steelers
• Projected Favorite & Spread: San Francisco by 4.6 points
• Time: 1:00 PM ET
• Date: September 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo

Take advantage of these best bet suggestions and bet on any game with BetMGM!

Best Week 1 Total Bets

Over 45 – Philadelphia vs. New England

• Matchup: Philadelphia Eagles at New England Patriots
• Projected Total: 45.3 points
• Time: 4:25 PM ET
• Date: September 10
• TV Channel: CBS
• Live Stream: Watch this game on Fubo

Under 52.5 – Detroit vs. Kansas City

• Matchup: Detroit Lions at Kansas City Chiefs
• Projected Total: 51.6 points
• Time: 8:20 PM ET
• Date: September 7
• TV Channel: NBC
• Live Stream: Watch this game on Fubo

Under 46.5 – Buffalo vs. New York

• Matchup: Buffalo Bills at New York Jets
• Projected Total: 41.4 points
• Time: 8:15 PM ET
• Date: September 11
• TV Channel: ABC/ESPN
• Live Stream: Watch this game on Fubo

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